Evaluation of triglyceride/high-density lipoprotein ratio as a surrogate marker for insulin resistance in healthy young males

Q3 Biochemistry, Genetics and Molecular Biology Journal of Natural Science, Biology, and Medicine Pub Date : 2021-07-01 DOI:10.4103/jnsbm.JNSBM_193_20
K. Sowndarya, J. Joseph, Amya Shenoy, A. Hegde
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引用次数: 10

Abstract

Background: Insulin resistance (IR) is the major underlying mechanism responsible for metabolic syndrome and HOMA-IR2 is a validated marker of IR. Fasting lipid profile, including triglyceride (TG) and high-density lipoprotein (HDL) cholesterol routinely feature in the outpatient investigation list. Utility of TG/HDL ratio as a surrogate marker for IR was thus studied in healthy young males. Materials and Methods: This cross-sectional study involved 71 young males aged 18–35 years who came for a routine health check in a fasting state. Height, weight, waist circumference were recorded. Fasting plasma glucose (FPG) and lipid profile reports were collected from the laboratory database. Fasting insulin (FI) was estimated by enzyme-linked immunosorbent assay. Body mass index (kg/m2), TG/HDL, TC/HDL, and HOMA-IR2 were calculated. Results: Mean TG/HDL ratio was 3.73 ± 2.03 and HOMA IR2 was above the standard cut off of ≥2.5 units. Subjects were further divided into two groups based on FPG values. TG, low-density lipoprotein, total cholesterol, TG/HDL, TC/HDL, FI and HOMA-IR2 were found to be higher in the pre-diabetes with impaired fasting glycemic subjects. Overall, a statistically significant positive correlation was seen (P = 0.01, r = 0.284) between TG/HDL and HOMA-IR2. Conclusion: TG/HDL ratio was significantly associated with IR and it could be used as an indicator of IR especially in prediabetic subjects having impaired fasting glucose.
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评价甘油三酯/高密度脂蛋白比率作为健康年轻男性胰岛素抵抗的替代标志物
背景:胰岛素抵抗(IR)是代谢综合征的主要潜在机制,HOMA-IR2是胰岛素抵抗的有效标志物。空腹血脂,包括甘油三酯(TG)和高密度脂蛋白(HDL)胆固醇在门诊调查名单中是常规特征。因此,在健康的年轻男性中研究了TG/HDL比率作为IR的替代标记物的效用。材料和方法:这项横断面研究涉及71名年龄在18-35岁之间的年轻男性,他们在禁食状态下进行常规健康检查。记录身高、体重、腰围。空腹血糖(FPG)和血脂报告从实验室数据库中收集。采用酶联免疫吸附法测定空腹胰岛素(FI)。计算体重指数(kg/m2)、TG/HDL、TC/HDL、HOMA-IR2。结果:平均TG/HDL比值为3.73±2.03,HOMA IR2高于标准临界值≥2.5单位。根据FPG值将受试者进一步分为两组。空腹血糖受损的糖尿病前期患者TG、低密度脂蛋白、总胆固醇、TG/HDL、TC/HDL、FI和HOMA-IR2均较高。总体而言,TG/HDL与HOMA-IR2呈显著正相关(P = 0.01, r = 0.284)。结论:TG/HDL比值与IR有显著相关性,尤其在空腹血糖受损的糖尿病前期患者中可作为IR的指标。
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来源期刊
Journal of Natural Science, Biology, and Medicine
Journal of Natural Science, Biology, and Medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
2.40
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0.00%
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0
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