R. Mervis, J. McKean, S. Zats, A. Gum, R. Reinhart, B. Dudas, U. Cornelli, John M. Lee, S. Lorens, J. Fareed, I. Hanin
{"title":"Neurotrophic Effects of the Glycosaminoglycan C3 on Dendritic Arborization and Spines in the Adult Rat Hippocampus: A Quantitative Golgi Study","authors":"R. Mervis, J. McKean, S. Zats, A. Gum, R. Reinhart, B. Dudas, U. Cornelli, John M. Lee, S. Lorens, J. Fareed, I. Hanin","doi":"10.1111/J.1527-3458.2000.TB00187.X","DOIUrl":null,"url":null,"abstract":"Glycosaminoglycans (GAGs) may be effective as a therapeutic strategy in the treatment of Alzheimer’s Disease (AD). Previous work from this group using a rat model showed that a single intra-amygdaloid injection of A$(25-35) could induce abnormal tauimmunoreactive perikarya in the hippocampus. Furthermore, administration of the GAG C3, an ultra low molecular weight heparin mixture of 4-10 oligosaccharides (MW~2.1) could decrease A$(25-35) -induced tau-2 immunoreactivity in this model of AD. In this study, we evaluated the effects of stereotaxic intra-amygdaloid injection of A$(25-35) (5 nml/3:l) and of C3-treatment (administered subcutaneously, s.c.) on dendritic morphology of Golgi-impregnated CA1 pyramids of the hippocampus. Subjects were young-adult, male F344 rats.","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"141 1","pages":"44-46"},"PeriodicalIF":0.0000,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"CNS drug reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/J.1527-3458.2000.TB00187.X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
Abstract
Glycosaminoglycans (GAGs) may be effective as a therapeutic strategy in the treatment of Alzheimer’s Disease (AD). Previous work from this group using a rat model showed that a single intra-amygdaloid injection of A$(25-35) could induce abnormal tauimmunoreactive perikarya in the hippocampus. Furthermore, administration of the GAG C3, an ultra low molecular weight heparin mixture of 4-10 oligosaccharides (MW~2.1) could decrease A$(25-35) -induced tau-2 immunoreactivity in this model of AD. In this study, we evaluated the effects of stereotaxic intra-amygdaloid injection of A$(25-35) (5 nml/3:l) and of C3-treatment (administered subcutaneously, s.c.) on dendritic morphology of Golgi-impregnated CA1 pyramids of the hippocampus. Subjects were young-adult, male F344 rats.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
