Pub Date : 2006-06-07DOI: 10.1111/J.1527-3458.2000.TB00166.X
R. Wurtman, C. Watkins, Robert K. K. Lee, Julian Agut, J. Ortiz
{"title":"Use of Citicoline, a Source of Blood Choline and Cytidine/Uridine, for Neuroprotection","authors":"R. Wurtman, C. Watkins, Robert K. K. Lee, Julian Agut, J. Ortiz","doi":"10.1111/J.1527-3458.2000.TB00166.X","DOIUrl":"https://doi.org/10.1111/J.1527-3458.2000.TB00166.X","url":null,"abstract":"","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"21 1","pages":"15-16"},"PeriodicalIF":0.0,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75397613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-06-07DOI: 10.1111/J.1527-3458.2000.TB00134.X
Yongxiang Wang, S. Bowersox
{"title":"Analgesic Properties of Ziconotide, a Selective Blocker of N‐Type Neuronal Calcium Channels","authors":"Yongxiang Wang, S. Bowersox","doi":"10.1111/J.1527-3458.2000.TB00134.X","DOIUrl":"https://doi.org/10.1111/J.1527-3458.2000.TB00134.X","url":null,"abstract":"","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"31 1","pages":"1-20"},"PeriodicalIF":0.0,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73676458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-06-07DOI: 10.1111/J.1527-3458.2000.TB00181.X
G. Marek, C. Zhang
{"title":"Excitatory Action of mGlu1/5 Receptor Activation in Layer V Pyramidal Cells of the Prefrontal Cortex","authors":"G. Marek, C. Zhang","doi":"10.1111/J.1527-3458.2000.TB00181.X","DOIUrl":"https://doi.org/10.1111/J.1527-3458.2000.TB00181.X","url":null,"abstract":"","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"78 1","pages":"38-38"},"PeriodicalIF":0.0,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78207695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-06-07DOI: 10.1111/J.1527-3458.2000.TB00139.X
A. Scriabine
{"title":"29th Annual Meeting of the Society for Neuroscience, Miami Beach, FL, USA, October 23 – 28, 1999 New Drugs Affecting the Central Nervous System","authors":"A. Scriabine","doi":"10.1111/J.1527-3458.2000.TB00139.X","DOIUrl":"https://doi.org/10.1111/J.1527-3458.2000.TB00139.X","url":null,"abstract":"","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"1 1","pages":"79-93"},"PeriodicalIF":0.0,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78554007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-06-07DOI: 10.1111/J.1527-3458.2000.TB00168.X
S. Roberts, J. Hendrick, A. Vinitsky, D. Barten, D. Izzarelli, Martin A. Lewis, B. Robertson, R. Wang, J. Corsa, V. Guss, C. Polson, D. Romaniello, P. V. Chaturvedula, K. Felsenstein, David W. Smith
{"title":"Symptomatic and Disease Modifying Treatments of Alzheimer's Disease","authors":"S. Roberts, J. Hendrick, A. Vinitsky, D. Barten, D. Izzarelli, Martin A. Lewis, B. Robertson, R. Wang, J. Corsa, V. Guss, C. Polson, D. Romaniello, P. V. Chaturvedula, K. Felsenstein, David W. Smith","doi":"10.1111/J.1527-3458.2000.TB00168.X","DOIUrl":"https://doi.org/10.1111/J.1527-3458.2000.TB00168.X","url":null,"abstract":"","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"190 1","pages":"19-19"},"PeriodicalIF":0.0,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73603745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-06-07DOI: 10.1111/J.1527-3458.2000.TB00162.X
P. Goldman-Rakic
{"title":"The Role of Dopamine D1 Receptors in Cognition","authors":"P. Goldman-Rakic","doi":"10.1111/J.1527-3458.2000.TB00162.X","DOIUrl":"https://doi.org/10.1111/J.1527-3458.2000.TB00162.X","url":null,"abstract":"","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"56 1","pages":"7-8"},"PeriodicalIF":0.0,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76247127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-06-07DOI: 10.1111/J.1527-3458.2000.TB00145.X
A. Scriabine
{"title":"29th Annual Meeting of New England Pharmacologists Brown University, Providence, RI January 28–29, 2000","authors":"A. Scriabine","doi":"10.1111/J.1527-3458.2000.TB00145.X","DOIUrl":"https://doi.org/10.1111/J.1527-3458.2000.TB00145.X","url":null,"abstract":"","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"38 1","pages":"179-182"},"PeriodicalIF":0.0,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86473292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-06-07DOI: 10.1111/J.1527-3458.2004.TB00020.X
G. Tian, C. Sobotka-Briner, J. Zysk, Xiaodong Liu, C. Birr, M. Sylvester, P. Edwards, Clay Scott, B. Greenberg
{"title":"Non‐Competitive Inhibition of Solubilized Human γ‐Secretase by Pepstatin A Methylester, L‐685458, Sulfonamides and Benzodiazepines","authors":"G. Tian, C. Sobotka-Briner, J. Zysk, Xiaodong Liu, C. Birr, M. Sylvester, P. Edwards, Clay Scott, B. Greenberg","doi":"10.1111/J.1527-3458.2004.TB00020.X","DOIUrl":"https://doi.org/10.1111/J.1527-3458.2004.TB00020.X","url":null,"abstract":"","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"1 1","pages":"198-198"},"PeriodicalIF":0.0,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86095877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-06-07DOI: 10.1111/J.1527-3458.2000.TB00167.X
P. W. Landfield, O. Thibault
{"title":"Regulation of Calcium Homeostatsis in Brain Aging – A Target for Neuroprotection","authors":"P. W. Landfield, O. Thibault","doi":"10.1111/J.1527-3458.2000.TB00167.X","DOIUrl":"https://doi.org/10.1111/J.1527-3458.2000.TB00167.X","url":null,"abstract":"","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"69 1","pages":"17-18"},"PeriodicalIF":0.0,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89158076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-06-07DOI: 10.1111/J.1527-3458.2000.TB00187.X
R. Mervis, J. McKean, S. Zats, A. Gum, R. Reinhart, B. Dudas, U. Cornelli, John M. Lee, S. Lorens, J. Fareed, I. Hanin
Glycosaminoglycans (GAGs) may be effective as a therapeutic strategy in the treatment of Alzheimer’s Disease (AD). Previous work from this group using a rat model showed that a single intra-amygdaloid injection of A$(25-35) could induce abnormal tauimmunoreactive perikarya in the hippocampus. Furthermore, administration of the GAG C3, an ultra low molecular weight heparin mixture of 4-10 oligosaccharides (MW~2.1) could decrease A$(25-35) -induced tau-2 immunoreactivity in this model of AD. In this study, we evaluated the effects of stereotaxic intra-amygdaloid injection of A$(25-35) (5 nml/3:l) and of C3-treatment (administered subcutaneously, s.c.) on dendritic morphology of Golgi-impregnated CA1 pyramids of the hippocampus. Subjects were young-adult, male F344 rats.
{"title":"Neurotrophic Effects of the Glycosaminoglycan C3 on Dendritic Arborization and Spines in the Adult Rat Hippocampus: A Quantitative Golgi Study","authors":"R. Mervis, J. McKean, S. Zats, A. Gum, R. Reinhart, B. Dudas, U. Cornelli, John M. Lee, S. Lorens, J. Fareed, I. Hanin","doi":"10.1111/J.1527-3458.2000.TB00187.X","DOIUrl":"https://doi.org/10.1111/J.1527-3458.2000.TB00187.X","url":null,"abstract":"Glycosaminoglycans (GAGs) may be effective as a therapeutic strategy in the treatment of Alzheimer’s Disease (AD). Previous work from this group using a rat model showed that a single intra-amygdaloid injection of A$(25-35) could induce abnormal tauimmunoreactive perikarya in the hippocampus. Furthermore, administration of the GAG C3, an ultra low molecular weight heparin mixture of 4-10 oligosaccharides (MW~2.1) could decrease A$(25-35) -induced tau-2 immunoreactivity in this model of AD. In this study, we evaluated the effects of stereotaxic intra-amygdaloid injection of A$(25-35) (5 nml/3:l) and of C3-treatment (administered subcutaneously, s.c.) on dendritic morphology of Golgi-impregnated CA1 pyramids of the hippocampus. Subjects were young-adult, male F344 rats.","PeriodicalId":10499,"journal":{"name":"CNS drug reviews","volume":"141 1","pages":"44-46"},"PeriodicalIF":0.0,"publicationDate":"2006-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86595540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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