Implementation of Signal Detection and Control of Bioartificial Liver Support System

Chang-Zhe Wu, Ke Li, Cheng Zhang, Guanghao Zhang, Xiao-Lin Huo
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Abstract

Liver failure is an extremely dangerous disease whose mortality rate is 73.9% and the rate of acute liver failure is as high as 87.8%. As the only effective way to treat liver failure, liver transportation is facing a serious shortage of donor. As an extracorporeal circulation device, artificial liver support system could effectively replace the patient's liver in a short period of time so as to improve the survival rate of patients greatly. At present, the control core of the artificial liver control system is PLC. However, with the increasing complexity of functions and demands, the control system based on PLC will gradually show some disadvantages in cost, safety, reliability, stability, real-time Performance and other aspects which will restrict the development of artificial liver. Aiming at the deficiencies in the existing control system, a bio-artificial embedded control system based on ARM and CPLD was designed and implemented in this study, completes the hardware design, PCB design and control program writing, and designs the safety control loop to improve the control system Reliability. The experimental results show that performance of the control system has been improved to a certain extent in terms of safety, reliability, stability and real-time performance. Meanwhile, the cost of control system is lower, which is conducive to the market promotion of artificial liver.
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生物人工肝支持系统信号检测与控制的实现
肝衰竭是一种极其危险的疾病,死亡率高达73.9%,急性肝衰竭的发生率高达87.8%。肝移植作为治疗肝功能衰竭的唯一有效途径,目前面临着供体严重短缺的问题。人工肝支持系统作为一种体外循环装置,可以在短时间内有效地替代患者的肝脏,从而大大提高患者的生存率。目前,人工肝脏控制系统的控制核心是PLC。然而,随着功能和需求的日益复杂,基于PLC的控制系统在成本、安全性、可靠性、稳定性、实时性等方面将逐渐显现出一些不足,这将制约人工肝脏的发展。针对现有控制系统的不足,本研究设计并实现了一种基于ARM和CPLD的生物人工嵌入式控制系统,完成了硬件设计、PCB设计和控制程序编写,并设计了安全控制回路,提高了控制系统的可靠性。实验结果表明,该控制系统在安全性、可靠性、稳定性和实时性等方面都有了一定程度的提高。同时,控制系统成本较低,有利于人工肝的市场推广。
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