RADIOPROTECTIVE PROPERTIES OF PHYTOMEDICINES: A LITERATURE REVIEW

Abstract

Relevance: Till today, antiradiation agents have been mainly found among radioprotectors synthesized from sulfur-containing compounds. The search for radioprotectors in other classes of compounds appeared to be less successful. The study aimed to analyze the pharmacodynamics of phytopreparations used to correct disorders of the immune and antioxidant systems and purine metabolism of the body induced by radiation. Methods: The review included publications indexed in PubMed, Medline, E-library, and CyberLeninka databases. The search was made using the Google Scholar scientific search engine. The search filters included: experimental studies performed on mice and rats over the past decade (2012 to 2022). Results: The literary search returned an insufficient number of publications on the qualities of the action of phytopreparations, such as integrity and complexity, the versatility of action, selectivity, and organotropism. The lack of publications on side effects (except for allergic intolerance to any components of plants) requires a profound study of this topic. Conclusion: Radiobiology should search for new non-drug means of treatment and make experiments to study the effect of phytocompositions on biochemical processes in an irradiated organism.