The correlation between the expression of LncRNA-OVAAL and the recurrence and prognosis of uterine papillary serous carcinoma after operation

Abstract

Objective To investigate the relationship between long non-coding ovarian adenocarcinoma amplified RNA (LncRNA-OVAAL) and tumor recurrence and prognosis in uterine papillary serous carcinoma (UPSC). Methods From May 2012 to November 2016, 32 patients with UPSC in our hospital were selected as observation group, and 30 patients with other benign diseases were selected as control group. Real-time polymerase chain reaction (PCR) was used to detect the expression of LncRNA-OVAAL in the enrolled patients. The receiver operating characteristic (ROC) curve was used to analyze the cutoff value of LncRNA-OVAAL. The relationship between LncRNA-OVAAL expression and clinicopathological features was analyzed. The cumulative survival rate was calculated and survival analysis was performed. The Cox risk regression model was used to analyze the single-factor and multi-factor analysis of prognosis and overall survival rate. Results The expression of LncRNA-OVAAL in patients with UPSC was elevated, which was related to age, vascular invasion, menopause, recurrence and preoperative serum human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125) (P<0.05). High expression of LncRNA-OVAAL was a risk factor for postoperative recurrence and overall survival in patients with UPSC (P<0.05). Conclusions The high expression of LncRNA-OVAAL has a certain evaluation value for predicting postoperative recurrence and prognosis in patients with UPSC. Key words: RNA, long noncoding; Uterine papillary serous carcinoma; Neoplasm recurrence; Prognosis