Protective effect of Oroxylum indicum on acetaminophen induced liver injury in rat

International Current Pharmaceutical Journal Pub Date : 2014-01-02 DOI:10.3329/ICPJ.V3I2.17511

M. Bharali, H. Konya, Luk Bahadur Chetry

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引用次数: 11

Abstract

Acetaminophen (APAP) is a common antipyretic drug and leads to liver failure at over dose. In this study, the hepatoprotective effect of Aqueous Methanolic Bark Extract of Oroxylum indicum (L.)Vent. ( AMBEOI ) has been evaluated in rat model. Rats were treated with 1000 mgkg ‐ 1 body weight of APAP alone or with AMBEOI (10, 50 and 100 mgkg ‐ 1 ). Serum Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Lipid peroxidation (LPO) in liver tissues were estimated 24 hrs after APAP and AMBEOI treatment. AMBEOI administration effectively reduced serum level of ALT and AST released from liver cells when compared to APAP treated group. AMBEOI also inhibited production of LPO in the liver tissues of APAP treated rats. Histopathological examination of liver samples revealed reduced necrotic areas in AMBEOI treated APAP group compared to APAP alone treated group. Together, this study confirmed the hepatoprotective activities of AMBEOI in APAP induced liver damage in rat. DOI: http://dx.doi.org/10.3329/icpj.v3i2.17511 International Current Pharmaceutical Journal, January 2014, 3(2): 223-227

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芡实对对乙酰氨基酚所致大鼠肝损伤的保护作用

对乙酰氨基酚(APAP)是一种常见的退烧药，过量可导致肝功能衰竭。在本研究中，研究了紫荆树皮乙醇水提物对肝脏的保护作用。(AMBEOI)在大鼠模型中进行了评价。将大鼠单独给予1000 mgkg‐1体重的APAP或AMBEOI(10、50和100 mgkg‐1)。测定APAP和AMBEOI治疗后24小时血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、肝组织脂质过氧化(LPO)水平。与APAP治疗组相比，AMBEOI有效降低血清中肝细胞释放的ALT和AST水平。AMBEOI还能抑制APAP处理大鼠肝组织中LPO的产生。肝脏组织病理学检查显示，AMBEOI治疗APAP组与单独治疗APAP组相比，坏死面积减少。综上所述，本研究证实了AMBEOI对APAP诱导的大鼠肝损伤的保护作用。DOI: http://dx.doi.org/10.3329/icpj.v3i2.17511国际现代医药杂志，2014年1月，3(2):223-227

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International Current Pharmaceutical Journal

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