Optimization of 18F Radioisotope Production with Cyclone 18/9 MeV IBA Cyclotron Installed at NINMAS

Afm Masum Rabbani, Md Shohag Mia, H. Mehdi, Sanchoy Chandra Biswasarma, Md Ariful Islam, Md. Jashim Uddin, T. Biman, Mohammad Anwar Ul Azim, M. Hossain
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Abstract

A cyclotron is a particle accelerator, which employs electromagnetic fields to accelerate charged particles to extremely high speeds and energy. It is used to create radioisotopes for radiopharmaceuticals, which are used to diagnose and treat cancer. Because cyclotron-produced radiopharmaceuticals are exceptionally effective in identifying various cancers. Cyclotrons are fast evolving and will play an increasingly important role in the healthcare industry, particularly in advanced medical imaging techniques like positron emission tomography-computed tomography (PET-CT) and single photon emission computed tomography (SPECT). An 18/9 MeV cyclotron (18 MeV for proton and 9 MeV for deuteron, Model: Cyclone 18/9, IBA) was installed at the National Institute of Nuclear Medicine and Allied Science (NINMAS), Bangladesh Atomic Energy Commission (BAEC). Radioisotopes such as 18F, 11C, 13N, and 15O can be produced with this cyclotron. Solid target option is also available here which can be used for producing 67Ga, 68Ga, 124I, 123I, 111In, 99mTc, 64Cu, and 89Zr radioisotopes. 18F is the radioisotope of choice for many radiopharmaceuticals due to its glucose analogous and half-life of 110 min. We are producing FDG on a regular basis. For a 60-minute bombardment time, a 40 to 50 micro amp beam current is employed to produce 18F with a mass of 2500 to 3500 mCi. Because of the variable production parameters used, the production of 18F varies. Parameters used in the production of 18F radioisotope are limited to physical factors such as target material, target volume, collimator, stripper foil, and ion source. As a result, we consider 18F yield to be the most important aspect in providing sufficient activity since we want to find the best operating point that minimizes both production time and cost. In order to produce an optimal 18F radioisotope production, all parameters such as dee voltage, vacuum label, beam current, irradiation time, amount of enriched 18O water, target pressure, and others are taken into account. Dhaka Univ. J. Sci. 71(1): 56-59, 2023 (Jan)
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利用安装在NINMAS的18/9 MeV IBA旋风回旋加速器优化18F放射性同位素生产
回旋加速器是一种粒子加速器,它利用电磁场将带电粒子加速到极高的速度和能量。它被用来制造用于诊断和治疗癌症的放射性药物的放射性同位素。因为回旋加速器产生的放射性药物在识别各种癌症方面非常有效。回旋加速器正在快速发展,并将在医疗保健行业中发挥越来越重要的作用,特别是在先进的医学成像技术中,如正电子发射断层扫描-计算机断层扫描(PET-CT)和单光子发射计算机断层扫描(SPECT)。孟加拉国原子能委员会(BAEC)国家核医学和联合科学研究所(NINMAS)安装了一个18/9 MeV的回旋加速器(质子18 MeV,氘核9 MeV,型号:Cyclone 18/9, IBA)。放射性同位素如18F、11C、13N和15O可以用这个回旋加速器产生。固体靶选择也可用于生产67Ga, 68Ga, 124I, 123I, 111In, 99mTc, 64Cu和89Zr放射性同位素。18F是许多放射性药物的首选放射性同位素,因为它与葡萄糖类似,半衰期为110分钟。我们定期生产FDG。在60分钟的轰击时间内,采用40至50微安的光束电流产生质量为2500至3500mci的18F。由于使用的生产参数不同,18F的产量也不同。18F放射性同位素生产中使用的参数受物理因素的限制,如靶材料、靶体积、准直器、剥离箔和离子源。因此,我们认为18F产量是提供足够活动力的最重要方面,因为我们希望找到最小化生产时间和成本的最佳作业点。为了获得最佳的18F放射性同位素产量,需要考虑所有参数,如dee电压、真空标签、束流、辐照时间、富集18O水的量、目标压力等。达卡大学学报(自然科学版),71(1):56-59,2023 (1)
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