Antiproliferative Properties of Leaf Extract of Hopea ponga (Dennst.) Mabberly

Abstract

OBJECTIVE: The present study aimed to evaluate the antiproliferative properties of hydroalchoholic extract of Hopea ponga leaves. METHODS: The antiproliferative capacity of extract was assessed by employing different assays such as by brine shrimp lethality assay, MTT assay and trypan blue assay in HeLa cells. Results were compared with standard vincristine. RESULTS: In vitro antiproliferative study of the hydroalcoholic extract of H.ponga was evaluated by brine shrimp lethality assay, MTT assay and trypan blue assay in HeLa cells. The results indicated that the hydroalcoholic extract of H. ponga possessed good antiproliferative property when compared to the standard drug vincristine. CONCLUSION: The result suggests that the hydroalochoholic extracts of H. ponga plays an important role in antiproliferative activity.The activity may be due to the presence of flavonoids. It is further suggested that in vivo studies and characterisation of fractionated extracts May be conducted in this extract, to establish its effect. Hopea ponga ( Dennst.)Mabberly. H. ponga has been used as a source of timbre for construction and agricultural implements shows its potential as being used as antiproliferative, anti-inflammatory and antioxidant, so it can be concluded that this species should be conserved and explored further.