Human telomerase reverse transcriptase as a major therapeutic target in different cancer types

Z. Singh, Priya Khangotra
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引用次数: 1

Abstract

Telomerase is a known global therapeutic target in cancer cells. Human telomerase reverse transcriptase (hTERT) is a catalytic subunit of the telomerase enzyme. hTERT is usually silenced in almost all somatic cells but it is significantly expressed in ~90 % of human cancers. Many cancer suppressing genes produce factors that hinder hTERT activity. Here, in this review paper, an attempt has been made to emphasize the role of hTERT in different cancer types. Various recent therapeutic studies involving hTERT suppression have also been discussed. Serum hTERT mRNA levels have been found to reflect the tumour burden and the clinical status of the patient. Nano-formulations like nano-curcumin and nano-chrysin have also been shown to significantly decrease hTERT gene expression in SW480 cells. High frequency of hTERT-promoting mutations and increased expression of hTERT mRNA makes it a suitable target in different cancer types. *Correspondence to: Zorawar Singh, Assistant Professor, Department of Zoology, Khalsa College Amritsar, Punjab, India, Tel: +91-94172-30075; E-mail: zorawarsinghs@rediffmail.com
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人类端粒酶逆转录酶作为不同癌症类型的主要治疗靶点
端粒酶是癌症细胞中已知的全球性治疗靶点。人类端粒酶逆转录酶(hTERT)是端粒酶的催化亚基。hTERT通常在几乎所有体细胞中沉默,但在约90%的人类癌症中显著表达。许多癌症抑制基因产生阻碍hTERT活性的因子。在这篇综述中,我们试图强调hTERT在不同癌症类型中的作用。最近各种涉及hTERT抑制的治疗研究也进行了讨论。已发现血清hTERT mRNA水平反映肿瘤负荷和患者的临床状态。纳米姜黄素和纳米黄素等纳米制剂也被证明可以显著降低SW480细胞中的hTERT基因表达。hTERT促进突变的高频率和hTERT mRNA表达的增加使其成为不同癌症类型的合适靶点。*通讯:印度旁遮普省阿姆利则卡尔萨学院动物学系助理教授Zorawar Singh,电话:+91-94172-30075;电子邮件:zorawarsinghs@rediffmail.com
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