Synthesis and Characterization of a Novel Zinc-Based Metal-Organic Framework Containing Benzoic Acid: A Low-Toxicity Carrier for Drug Delivery.

IF 0.5 Q3 AREA STUDIES 中国报道 Pub Date : 2023-07-14 eCollection Date: 2023-01-01 DOI:10.5812/ijpr-136238

Xiaomei Ye, Mengmeng Xiong, Kangrui Yuan, Wei Liu, Xiaoqun Cai, Yu Yuan, Yanghang Yuan, Youfa Qin, Dudu Wu

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Abstract

In recent years, metal-organic frameworks (MOFs) have gained attention in the biomedical field, particularly as drug carriers for treating tumors. Therefore, we decided to synthesize a novel benzoic acid Zn-based MOF and study the Zn-based MOFs' drug-delivery properties and the drug-delivery system's anticancer effects. This study successfully synthesized a zinc-based MOF using solvent thermal synthesis. The crystal structure of a Zn-based MOF was investigated using thermogravimetric analysis, X-ray diffraction, and Fourier transform infrared spectroscopy. Subsequently, the results of UV spectrophotometry showed that Doxorubicin was successfully loaded with a loading amount of 33.74%. Furthermore, the drug release experiments demonstrated that the Zn-based MOF was pH-sensitive, releasing more at a pH of 3.8 than at pH 5.8 or 7.4. Finally, the Zn-based MOF loaded with drugs exhibited high antitumor activity against HepG2 cells while demonstrating remarkably low toxicity to normal cells (LO2). Taken together, these results demonstrate that the Zn-based MOF has the potential to serve as a carrier in the field of drug delivery systems.

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含苯甲酸的新型锌基金属有机框架的合成与表征：一种低毒性药物载体。

近年来，金属有机框架（MOFs）在生物医学领域备受关注，尤其是作为治疗肿瘤的药物载体。因此，我们决定合成一种新型苯甲酸锌基 MOF，并研究锌基 MOF 的给药性能和给药系统的抗癌效果。本研究采用溶剂热合成法成功合成了锌基MOF。利用热重分析、X 射线衍射和傅立叶变换红外光谱研究了锌基 MOF 的晶体结构。随后，紫外分光光度法的结果表明，多柔比星被成功负载，负载量为 33.74%。此外，药物释放实验表明，锌基 MOF 对 pH 值很敏感，在 pH 值为 3.8 时的释放量高于 pH 值为 5.8 或 7.4 时的释放量。最后，负载药物的 Zn 基 MOF 对 HepG2 细胞具有很高的抗肿瘤活性，同时对正常细胞（LO2）的毒性也很低。综上所述，这些结果表明锌基 MOF 有潜力成为药物输送系统领域的载体。

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来源期刊

中国报道 AREA STUDIES-

CiteScore

1.70

自引率

0.00%

发文量

9353

期刊介绍： China Report promotes the free expression and discussion of different ideas, approaches and viewpoints which assist a better understanding of China and its East Asian neighbours. A quarterly journal of the Institute of Chinese Studies, it attempts to provide a fresh approach which goes beyond the strictly utilitarian area studies without becoming antiquarian. Launched in 1964, China Report has, over the years, widened its interests and aims and transformed itself into a scholarly journal that seeks a better understanding of China and its East Asian neighbours - particularly their cultures, their development and their relations with China. It is an indispensable source of information on China, its society and culture.