Cardioprotective effect of Angiotensin (1-7) on myocardial infarction: Possible role of Nitric oxide and prostaglandins.

Zienab Abdullah, S. Helmy, Hanaa G. Elserougy, A. Abbas, Gehan A. Alwakeel
{"title":"Cardioprotective effect of Angiotensin (1-7) on myocardial infarction: Possible role of Nitric oxide and prostaglandins.","authors":"Zienab Abdullah, S. Helmy, Hanaa G. Elserougy, A. Abbas, Gehan A. Alwakeel","doi":"10.21608/BESPS.2018.8217","DOIUrl":null,"url":null,"abstract":"Objective: to detect the possible cardioprotective effect of Ang-(1-7) in rat model of MI; Also, possible role of NO and PGs in this probable cardioprotective effect of Ang- (1-7) was studied. Methods: Rats were divided randomly into 6 groups (8 rats each): Group I : Control group:, Group II: rats received S.C isoprenaline at a dose of 150 mg/kg/day on two consecutive days with an interval of 24 hours between applications, Group III: rats received Ang (1-7) (576μg/kg/day) S.C for 6 days after induction of MI ,Group IV: in which rats received Ang (1-7) (576μg/kg/day)+ L-NAME in the drinking water (80 mg/l) for 6days after induction of MI ,Group V: in which rats received Ang (1-7) (576μg/kg/day) +Indomethacin 5 mg/kg/day IP for 6 days after induction of MI ,Group VI: in which rats received both Ang-(1-7)+ L- NAME and Indomethacinat dose mentioned previously. Biochemical, histopathologial , and ECG changes were studied \nResults: ISO –MI group exhibited a significant rise in serum cardiac enzymes and disturbed lipid profile, increased myocardial damage score and Caspase3 expression when it is compared to the normal group (p<0.001). ECG changes of rat revealed elevation ST segment, QT interval prolongation, decrease QRS duration and voltage, and accelerated heart rate. Ang-(1-7) caused significant improvement in the studied parameters ,while co-infusion of L-NAME and or indomethacin prevent this effect of Ang-(1-7) .Combined L-NAME and  indomethacin produce more deleterious effect than separate administration of them. Conclusion: Ang-(1-7) is considered one of the cardioprotective components of RAS .NO and PGs mediate the action of Ang-(1-7) and they may have an additive effect.","PeriodicalId":9347,"journal":{"name":"Bulletin of Egyptian Society for Physiological Sciences","volume":"39 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Egyptian Society for Physiological Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/BESPS.2018.8217","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: to detect the possible cardioprotective effect of Ang-(1-7) in rat model of MI; Also, possible role of NO and PGs in this probable cardioprotective effect of Ang- (1-7) was studied. Methods: Rats were divided randomly into 6 groups (8 rats each): Group I : Control group:, Group II: rats received S.C isoprenaline at a dose of 150 mg/kg/day on two consecutive days with an interval of 24 hours between applications, Group III: rats received Ang (1-7) (576μg/kg/day) S.C for 6 days after induction of MI ,Group IV: in which rats received Ang (1-7) (576μg/kg/day)+ L-NAME in the drinking water (80 mg/l) for 6days after induction of MI ,Group V: in which rats received Ang (1-7) (576μg/kg/day) +Indomethacin 5 mg/kg/day IP for 6 days after induction of MI ,Group VI: in which rats received both Ang-(1-7)+ L- NAME and Indomethacinat dose mentioned previously. Biochemical, histopathologial , and ECG changes were studied Results: ISO –MI group exhibited a significant rise in serum cardiac enzymes and disturbed lipid profile, increased myocardial damage score and Caspase3 expression when it is compared to the normal group (p<0.001). ECG changes of rat revealed elevation ST segment, QT interval prolongation, decrease QRS duration and voltage, and accelerated heart rate. Ang-(1-7) caused significant improvement in the studied parameters ,while co-infusion of L-NAME and or indomethacin prevent this effect of Ang-(1-7) .Combined L-NAME and  indomethacin produce more deleterious effect than separate administration of them. Conclusion: Ang-(1-7) is considered one of the cardioprotective components of RAS .NO and PGs mediate the action of Ang-(1-7) and they may have an additive effect.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
血管紧张素(1-7)对心肌梗死的保护作用:一氧化氮和前列腺素的可能作用。
目的:探讨心肌梗死大鼠模型中Ang-(1-7)可能的心脏保护作用;此外,NO和pg在Ang-(1-7)可能的心脏保护作用中的可能作用也被研究。方法:大鼠随机分为6组老鼠(8):团队我:对照组:,组2:老鼠收到南卡罗来纳州异丙肾上腺素的剂量150毫克/公斤/日连续两天在应用程序之间的间隔24小时,第三组:大鼠收到盎(1 - 7)(576μg /公斤/天)诱导MI南卡罗来纳州6天后,第四组:大鼠的收到和(1 - 7)(576μg /公斤/天)+ L-NAME饮用水(80 mg / l)诱导的心肌梗死后6天,集团V:其中,大鼠在心肌梗死诱导后给予Ang (1-7) (576μg/kg/day) +吲哚美辛5 mg/kg/day IP,持续6 d;第六组:同时给予Ang-(1-7)+ L- NAME和上述剂量的吲哚美辛。结果:与正常组比较,ISO -MI组血清心肌酶、血脂紊乱、心肌损伤评分、Caspase3表达均显著升高(p<0.001)。大鼠心电图变化表现为ST段抬高,QT间期延长,QRS持续时间缩短,QRS电压降低,心率加快。Ang-(1-7)对研究参数有显著改善作用,而L-NAME和/或吲哚美辛联用可阻止Ang-(1-7)的作用。L-NAME和吲哚美辛联用比单独给药更有害。结论:Ang-(1-7)被认为是RAS的心脏保护成分之一,no和pg介导了Ang-(1-7)的作用,可能具有加性作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Targeting autophagy explaining therapeutic potential of silymarin against streptozotocin-induced type 2 diabetic nephropathy in a rat model: A histological and immunohistochemical study. Ashwagandha Seeds Extract Supplementation Afford Comparable Therapeutic Effect to Proton Pump Inhibitors in Stress induced Gastric Ulcer in rats In vivo evaluation of anti- Alzheimer impact of Asparagus sprengeri and Lactobacillus plantarum Effect of high fat diet (HFD)-induced obesity on gene expression of adipose tissue macrophage markers in male rats with different ages: Role of AMPK/SIRT1 pathway. Ameliorative effect of resveratrol against type 2 diabetes in rats through triggering of autophagy and inhibition of mTOR pathway.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1