The Cytotoxic Effect of PM 701 and its Fractions on Cell Proliferation of Breast Cancer Cells, McF7

World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering Pub Date : 2011-01-21 DOI:10.3923/AJDD.2011.200.208

F. Khorshid

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引用次数: 14

Abstract

Breast cancer is the most common malignancy in the world among women. Many therapies have been designed to treat this disease. Mamectomy, chemotherapy and radiotherapy are still the main therapies of breast cancer. However, the results were unsatisfactory and still far from the ideal treatment. PM 701is a natural product, has anticancer activity. The bioactive fraction PMF and subfraction PMFK had been isolated from PM701. PM 701 and its fractions were proved to have a cytotoxic properties against different cancer cell lines. This article is directed for the further examination of lyophilized PM701 and its active fractions on the growth of breast cancer cells (MCF-7). PM 701, PMF or PMFK were adding to the cultural medium, where MCF-7 is incubated. PM 701, PMF or PMFK were able to inhibit significantly the proliferation of MCF-7 cells, Moreover these new agents were proved to induce apoptosis of the breast cancer cells; through its direct effect on the nuclei. Keywords—Anticancer agent, breast carcinoma, MCF-7 cell line, PM 701

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pm701及其组分对乳腺癌细胞McF7增殖的细胞毒作用

乳腺癌是世界上女性中最常见的恶性肿瘤。已经设计了许多疗法来治疗这种疾病。乳房切除术、化疗和放疗仍然是乳腺癌的主要治疗方法。然而，结果并不令人满意，离理想的治疗还有很长的路要走。pm701是一种天然产物，具有抗癌活性。从PM701中分离得到生物活性组分PMF和亚组分PMFK。pm701及其组分对不同的肿瘤细胞系具有细胞毒性。本文旨在进一步探讨冻干PM701及其活性组分对乳腺癌细胞(MCF-7)生长的影响。将pm701, PMF或PMFK加入培养液中，MCF-7在培养液中孵育。pm701、PMF或PMFK均能显著抑制MCF-7细胞的增殖，并能诱导乳腺癌细胞凋亡;通过它对原子核的直接作用。关键词:抗癌药物，乳腺癌，MCF-7细胞系，pm701

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World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering

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