Regioselective Syntheses of 3-Benzyl-Substituted 7H-Thiazolo(3,2-a)pyrimidine-7-ones through Palladium-Catalyzed Heteroannulation of Acetylenic Compounds
{"title":"Regioselective Syntheses of 3-Benzyl-Substituted 7H-Thiazolo(3,2-a)pyrimidine-7-ones through Palladium-Catalyzed Heteroannulation of Acetylenic Compounds","authors":"M. Bakherad, Farzaneh Gholipoor","doi":"10.1155/2012/956584","DOIUrl":null,"url":null,"abstract":"An efficient synthesis of 3-benzyl-substituted 7H-thiazolo[3,2-a]pyrimine-7-ones in acetonitrile is accomplished via Pd- and Cu-catalyzed reaction of 2-mercaptopropargylpyrimidone with various aryl iodides in the presence of triethylamine as the base.","PeriodicalId":19688,"journal":{"name":"Organic Chemistry International","volume":"29 1","pages":"1-5"},"PeriodicalIF":0.0000,"publicationDate":"2012-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Chemistry International","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2012/956584","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
An efficient synthesis of 3-benzyl-substituted 7H-thiazolo[3,2-a]pyrimine-7-ones in acetonitrile is accomplished via Pd- and Cu-catalyzed reaction of 2-mercaptopropargylpyrimidone with various aryl iodides in the presence of triethylamine as the base.
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