New Strategies of Antibiotic Development

Abstract

Since discovery of wonder drug penicillin by Sir Alexander Flaming, many antibiotics have already been discovered while many others are in process of development and clinical evaluation. However a newly discovered antibiotics has a short valuable life time since its long term clinical use results into development of resistance in target pathogens rendering the antibiotics ineffective against its target(s)). Therefore for antibiotics to remain in demand for clinical use. So efforts are needed towards search for antibiotics with unique scaffolds and/or novel mechanism of action besides useful shelf and clinical life time. Some of  the promising strategies to accomplish this goal are: (a) Finding new antibiotics from old microbial sources, (b) Finding new microbial sources of antibiotics, (c) Accessing greater bacterial diversity thus exploiting known/unknown microbial sources in large numbers, (d) Adapting novel culture techniques. The paper draws focus on some valuable clues in finding new antibiotics