{"title":"Synthesis and Characterization of Hydrogel of Chitosan-Poly (N-Vinyl-2-Pirrolidone) (PVP)- Alginate for Ibuprofen Release","authors":"Kartini Afriani, Trisutanti Budikania","doi":"10.21776/ub.jpacr.2020.009.03.558","DOIUrl":null,"url":null,"abstract":"Hydrogels chitosan-poly-(N-vinyl-pyrrolidone)-alginate (Ch/PVP/Alg) have been synthesized with Ca2+, Zn2+ and formaldehyde as crosslinker. Hydrogels with ratio polymer 70:20:10 give a high swelling ratio and good network. The Ch/PVP/Alg/Ca2+ has 463.73% swelling ratio and 80.59% gel. Ch/PVP/Alg/Zn has 489.21% swelling ratio and 81.67% gel. Ch/PVP/Alg crosslinked with formaldehyde result 488.03% swelling ratio and 85.34% gel. Dissolution test of hydrogels in pH 1.2 releases ibuprofen less than 30%. Whereas in the pH 7.4, the release of ibuprofen by hydrogels are relatively high. Ch/PVP/Alg/Ca reach up to 34.63% in 30 minutes and 40.86% for Ch/PVP/Alg/Zn. Meanwhile Ch/PVP/Alg/CH2O can release 44.92% of ibuprofen in 30 minutes. The obtained hydrogel was characterized using infrared (FTIR) spectrophotometry, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM).","PeriodicalId":22728,"journal":{"name":"The Journal of Pure and Applied Chemistry Research","volume":"24 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Pure and Applied Chemistry Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21776/ub.jpacr.2020.009.03.558","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
Hydrogels chitosan-poly-(N-vinyl-pyrrolidone)-alginate (Ch/PVP/Alg) have been synthesized with Ca2+, Zn2+ and formaldehyde as crosslinker. Hydrogels with ratio polymer 70:20:10 give a high swelling ratio and good network. The Ch/PVP/Alg/Ca2+ has 463.73% swelling ratio and 80.59% gel. Ch/PVP/Alg/Zn has 489.21% swelling ratio and 81.67% gel. Ch/PVP/Alg crosslinked with formaldehyde result 488.03% swelling ratio and 85.34% gel. Dissolution test of hydrogels in pH 1.2 releases ibuprofen less than 30%. Whereas in the pH 7.4, the release of ibuprofen by hydrogels are relatively high. Ch/PVP/Alg/Ca reach up to 34.63% in 30 minutes and 40.86% for Ch/PVP/Alg/Zn. Meanwhile Ch/PVP/Alg/CH2O can release 44.92% of ibuprofen in 30 minutes. The obtained hydrogel was characterized using infrared (FTIR) spectrophotometry, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM).
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