Nanoscale metal particles as nanocarriers in targeted drug delivery system

N. A. C. Lah, M. Samykano, S. Trigueros
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引用次数: 12

Abstract

In the recent years, noble metal particles such as gold (Au) and silver (Ag) have been used progressively as efficient and safe nanoscale drug carriers in treating malignant as cites of cancerous cells. These single crystal structures of functionalised thearapeutic particles with the size less than 100 nm in diameter had proven offered an excellent function to modulate the oxidative stress and toxicity at affected membrane cells particularly to achieve the site-specific delivery of drugs. This mini-review will highlight the current advances of Au and Ag nanoscale particles as smart chemotherapeutic molecule carriers to these malignancies in impeding cancer cell activities locally. The paper also reviewed valuable insights of their efficacy in maintaining and precisely control the drugs release level within the therapeutic windows.
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纳米金属颗粒作为靶向给药系统的纳米载体
近年来,金(Au)和银(Ag)等贵金属颗粒作为高效、安全的纳米级药物载体逐渐被用于治疗恶性肿瘤。这些直径小于100纳米的功能化治疗颗粒的单晶结构已被证明在调节受影响膜细胞的氧化应激和毒性方面具有出色的功能,特别是在实现药物的位点特异性递送方面。这篇综述将重点介绍Au和Ag纳米颗粒作为恶性肿瘤的智能化疗分子载体在局部阻止癌细胞活动方面的最新进展。本文还回顾了它们在维持和精确控制治疗窗口内药物释放水平方面的有效性的宝贵见解。
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