Synthesis, Structure and Antiproliferative Activity of Cationic Porphyrin - Imidazophenazine Conjugate

L. Dubey, Mykola M. Ilchenko, V. Zozulya, O. Ryazanova, P. Pogrebnoy, I. Dubey
{"title":"Synthesis, Structure and Antiproliferative Activity of Cationic Porphyrin - Imidazophenazine Conjugate","authors":"L. Dubey, Mykola M. Ilchenko, V. Zozulya, O. Ryazanova, P. Pogrebnoy, I. Dubey","doi":"10.15866/IREBIC.V2I4.1527","DOIUrl":null,"url":null,"abstract":"New conjugate of G-quadruplex ligand, cationic tris(methylpyridinium)porphyrin, and its Zn(II) and Mn(III) metal complexes with a neutral intercalating agent imidazophenazine were synthesized. The synthesis was based on the coupling of carboxyalkyl derivative of the porphyrin with N1-aminoalkylated dye. Spectral-fluorescent studies and density functional quantum-chemical calculations suggest the formation of intramolecular complexes between the two chromophores for non-metalated hybrid and zinc(II) derivative. The conjugates have been found to inhibit the growth of tumor cells of mouse Lewis lung carcinoma in vitro at micromolar concentrations. Metal complexes were several times more active than the non-metalated hybrid. The most efficient Zn(II) complex suppressed the tumor cells with IC50 5.9 M","PeriodicalId":14377,"journal":{"name":"International Review of Biophysical Chemistry","volume":"79 1","pages":"147-152"},"PeriodicalIF":0.0000,"publicationDate":"2011-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Review of Biophysical Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15866/IREBIC.V2I4.1527","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5

Abstract

New conjugate of G-quadruplex ligand, cationic tris(methylpyridinium)porphyrin, and its Zn(II) and Mn(III) metal complexes with a neutral intercalating agent imidazophenazine were synthesized. The synthesis was based on the coupling of carboxyalkyl derivative of the porphyrin with N1-aminoalkylated dye. Spectral-fluorescent studies and density functional quantum-chemical calculations suggest the formation of intramolecular complexes between the two chromophores for non-metalated hybrid and zinc(II) derivative. The conjugates have been found to inhibit the growth of tumor cells of mouse Lewis lung carcinoma in vitro at micromolar concentrations. Metal complexes were several times more active than the non-metalated hybrid. The most efficient Zn(II) complex suppressed the tumor cells with IC50 5.9 M
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
阳离子卟啉-咪唑吩偶联物的合成、结构及抗增殖活性研究
合成了g -四络合物阳离子三(甲基吡啶)卟啉及其与中性插层剂咪唑非那嗪的锌(II)和锰(III)金属配合物。卟啉的羧基烷基衍生物与n -氨基烷基化染料偶联合成。光谱荧光研究和密度泛函量子化学计算表明,非金属化杂化和锌(II)衍生物的两个发色团之间形成了分子内配合物。该偶联物在体外微摩尔浓度下抑制小鼠Lewis肺癌肿瘤细胞的生长。金属配合物的活性是非金属杂化物的几倍。最有效的Zn(II)复合物抑制肿瘤细胞的IC50为5.9M
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Biocoagulants for Water and Waste Water Purification: a Review Optimisation of Poly(γ-Glutamic Acid) Production by Bacillus velezensis NRRL B – 23189 in Liquid Fermentation with Molasses as the Carbon Source without Addition of Glutamic Acid Effects of Transesterification Parameters on the Biodiesel Produced from Crude Groundnut Oil Effect of Filling Kinetic of Sequencing Batch Reactor on the Poultry Wastewater Treatment Technology and Engineering of Biodiesel Production: a Comparative Study between Microalgae and Other Non-Photosynthetic Oleaginous Microbes
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1