N-terminal pro-brain natriuretic peptide predicts instent restenosis in patients with stable coronary artery disease

Abstract

Aim: Instent restenosis is associated with a poor outcomes in coronary artery disease patients. There are many factors and mechanisms that contribute to the development of IRS. Some of clinical trials have been shown that N-Terminal –pro Brain Nnatriuretic Peptide has an important prognostic value in coronary artery disease. we aimed to evaluate the relationship between stent restenosis and N-Terminal–pro Brain Nnatriuretic Peptide in patients of stable coronary artery disease undergo percutaneous coronary intervention. Material and Methods: 411 patients with stent implantation due to stable coronary artery disease were evaluated and eighty patients underwent re-coronary angiography because of recurrent angina. NT-proBNP measured before coronary intervention. The patients were divided into two groups of instent restenosis developed and undeveloped. Results: In the multivariate regression analysis; Age (OR = 1.067; 95% CI 1.002-1136, P = 0.042) and NT-proBNP (OR = 1.023, 95% CI 1.008-1.038.p = 0.002). ) have been shown that they were independent predictors of IRS. The optimal threshold NT-pro BNP value for predicting IRS was >111, with a 56.5% sensitivity and 92% specificity (area under the curve [AUC]: 0.749, 95% CI: 0.639-0.840, P