Pub Date : 2018-01-01DOI: 10.5455/JTOMC.2018.01.06
Örgün Güneş
Acute appendicitis is a frequent cause of acute abdomen in general surgery (1). The most important factor is the lumen obstruction while the most frequent reason of such an obstruction is faeces ( 2). As the distal end of appendix is free, different localizations may cause difficulties during diagnosis and surgery. Especially, appendicitis cases with retrocaecal extension cause challenges in diagnosis and treatment for surgeons. A 20 years old male patient applied to the emergency service with an abdominal pain starting a day before. His examination revealed tenderness, defense and rebound in right lower quadrant and suprapubic region. Other system examinations were normal. The medical history of the patient did not include any significant prior illness. White blood cell count was 17.200 mm3, CRP was 0.43 mg/dl (0-1) and full urine analysis was 173 bacteria (0-60). In radiological examinations, the patient’s standing direct abdominal graph revealed no abnormality.
{"title":"A case report of retrocaecal acute appendicitis with ureteral involvement due to inflammation.","authors":"Örgün Güneş","doi":"10.5455/JTOMC.2018.01.06","DOIUrl":"https://doi.org/10.5455/JTOMC.2018.01.06","url":null,"abstract":"Acute appendicitis is a frequent cause of acute abdomen in general surgery (1). The most important factor is the lumen obstruction while the most frequent reason of such an obstruction is faeces ( 2). As the distal end of appendix is free, different localizations may cause difficulties during diagnosis and surgery. Especially, appendicitis cases with retrocaecal extension cause challenges in diagnosis and treatment for surgeons. A 20 years old male patient applied to the emergency service with an abdominal pain starting a day before. His examination revealed tenderness, defense and rebound in right lower quadrant and suprapubic region. Other system examinations were normal. The medical history of the patient did not include any significant prior illness. White blood cell count was 17.200 mm3, CRP was 0.43 mg/dl (0-1) and full urine analysis was 173 bacteria (0-60). In radiological examinations, the patient’s standing direct abdominal graph revealed no abnormality.","PeriodicalId":17427,"journal":{"name":"Journal of Turgut Ozal Medical Center","volume":"74 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75332249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.5455/JTOMC.2018.01.013
V. Oter, M. Yalçın, S. Oter
{"title":"The results of emergent curative surgery for the colorectal cancer; a single center experience of 52 patients","authors":"V. Oter, M. Yalçın, S. Oter","doi":"10.5455/JTOMC.2018.01.013","DOIUrl":"https://doi.org/10.5455/JTOMC.2018.01.013","url":null,"abstract":"","PeriodicalId":17427,"journal":{"name":"Journal of Turgut Ozal Medical Center","volume":"66 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80133854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.5455/jtomc.2018.01.016
Z. Yener, O. Celbiş
Sudden cardiac death is described as death that occur within the 1st hour of the onset of the symptoms or death within the 24 hours of the onset of symptoms in unwitnessesed deaths. Studies conducted in our country reveal that cardiovascular origined deaths are the most frequent, with a rate of 20% of all deaths. Although sudden deaths in young people are rare, it is important to perform a detailed autopsy and other required procedures. The etiology of the sudden death is hard to determine for the forensic doctors and in 5-1% of all cases no certain cause is determined despite the macroscopic, toxicologic and histopathologic evaluations. European Society of Cardiovascular Pathology also recommends performing molecular autopsy when the certain cardiac cause cannot be determined morphological. This review aims to offer genetical consulting to the family members of the sudden cardiac death cases and clarify the etiology of death via genetical evaluation if the macroscopic, toxicologic and histopathologic examinations fail to explain the cause of the sudden cardiac death especially in children and young adults. The most important problems in our country are the lack of multidisiplinary approach and standardized management methods. In our country molecular autopsy is only considered in rare and selected cases, but if these genetical evaluations were made more applicable and accessible via interdepartmental agreements and the application of new genetical diagnosis methods, it would be possible to develop standardized methods for the case selection of molecular autopsies in the future.
{"title":"Autopsy in sudden cardiac deaths","authors":"Z. Yener, O. Celbiş","doi":"10.5455/jtomc.2018.01.016","DOIUrl":"https://doi.org/10.5455/jtomc.2018.01.016","url":null,"abstract":"Sudden cardiac death is described as death that occur within the 1st hour of the onset of the symptoms or death within the 24 hours of the onset of symptoms in unwitnessesed deaths. Studies conducted in our country reveal that cardiovascular origined deaths are the most frequent, with a rate of 20% of all deaths. Although sudden deaths in young people are rare, it is important to perform a detailed autopsy and other required procedures. The etiology of the sudden death is hard to determine for the forensic doctors and in 5-1% of all cases no certain cause is determined despite the macroscopic, toxicologic and histopathologic evaluations. European Society of Cardiovascular Pathology also recommends performing molecular autopsy when the certain cardiac cause cannot be determined morphological. This review aims to offer genetical consulting to the family members of the sudden cardiac death cases and clarify the etiology of death via genetical evaluation if the macroscopic, toxicologic and histopathologic examinations fail to explain the cause of the sudden cardiac death especially in children and young adults. The most important problems in our country are the lack of multidisiplinary approach and standardized management methods. In our country molecular autopsy is only considered in rare and selected cases, but if these genetical evaluations were made more applicable and accessible via interdepartmental agreements and the application of new genetical diagnosis methods, it would be possible to develop standardized methods for the case selection of molecular autopsies in the future.","PeriodicalId":17427,"journal":{"name":"Journal of Turgut Ozal Medical Center","volume":"195 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76947541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.5455/jtomc.2018.02.036
N. Karaarslan, I. Yilmaz, F. Akgün, T. Çalişkan, M. Doğan, B. Bilir, O. Ates
Aim: Spondylodiscitis, if not diagnosed on time, can cause morbidity or mortality at high rates. This study was carried out with the aim of testing the hypothesis that “neutrophil-to-lymphocyte ratio can be used” especially in cases where it is difficult to diagnose spondylodiscitis. Material and Methods: This study involved 24 patients admitted to the State Hospital of Ministry of Health and Namik Kemal University for spondylodiscitis between January2014 and June2017. After excluding the cases that did not meet the inclusion criteria (n=6), the remaining cases (n=24) were referred to as the study group. A control group was created from healthy volunteers (n=24) who applied for routine physical checkups at the clinic between the same dates and who were similar in terms of age, sex, and body mass index to the study group. Hemogram parameters of the cases in both groups; white blood cell, C-reactive protein, erythrocyte sedimentation rate, and neutrophil-to-lymphocyte ratio were statistically compared. Results: Patients in the spondylodiscitis group, compared to healthy volunteers had statistically significant neutrophil-to-lymphocyte ratio value. Conclusion: Especially in cases where the diagnosis of spondylodiscitis is not assured, the neutrophil-to-lymphocyte ratio parameter, which is less costly than other diagnostic methods and the analysis results of which can be obtained in a shorter time, may be used to support clinical diagnosis.
{"title":"Evaluation of Neutrophil-to-lymphocyte ratio as a marker of inflammatory response in Spondylodiscitis","authors":"N. Karaarslan, I. Yilmaz, F. Akgün, T. Çalişkan, M. Doğan, B. Bilir, O. Ates","doi":"10.5455/jtomc.2018.02.036","DOIUrl":"https://doi.org/10.5455/jtomc.2018.02.036","url":null,"abstract":"Aim: Spondylodiscitis, if not diagnosed on time, can cause morbidity or mortality at high rates. This study was carried out with the aim of testing the hypothesis that “neutrophil-to-lymphocyte ratio can be used” especially in cases where it is difficult to diagnose spondylodiscitis. Material and Methods: This study involved 24 patients admitted to the State Hospital of Ministry of Health and Namik Kemal University for spondylodiscitis between January2014 and June2017. After excluding the cases that did not meet the inclusion criteria (n=6), the remaining cases (n=24) were referred to as the study group. A control group was created from healthy volunteers (n=24) who applied for routine physical checkups at the clinic between the same dates and who were similar in terms of age, sex, and body mass index to the study group. Hemogram parameters of the cases in both groups; white blood cell, C-reactive protein, erythrocyte sedimentation rate, and neutrophil-to-lymphocyte ratio were statistically compared. Results: Patients in the spondylodiscitis group, compared to healthy volunteers had statistically significant neutrophil-to-lymphocyte ratio value. Conclusion: Especially in cases where the diagnosis of spondylodiscitis is not assured, the neutrophil-to-lymphocyte ratio parameter, which is less costly than other diagnostic methods and the analysis results of which can be obtained in a shorter time, may be used to support clinical diagnosis.","PeriodicalId":17427,"journal":{"name":"Journal of Turgut Ozal Medical Center","volume":"8 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77168436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.5455/JTOMC.2018.01.024
T. Allahverdi, Harun Bayram, Kenan Binnetoğlu, T. Anuk, U. Bulut
Aim: We investigated the postoperative parathormone levels and the incidence of hypocalcemia in patients who had inadvertently underwent parathyroidectomy during thyroid surgery . Material and Methods: We retrospectively evaluated a total of 142 patients who had undergone thyroidectomy between January 2011 and March 2017 from their charts. The demographic feature sand pathology diagnoses of the thyroidectomy patients were evaluated. The number of excised parathyroid glands in the pathology specimens and their location were determined. The PTH level was checked after surgery. Calcium was measured on the 2nd day. Calcium replacement was provided for patients with low PTH and calcium. The level of calcium replacement was determined by referring to biochemical values. Following discharge, the calcium and PTH levels were checked during outpatient visits to determine whether the hypocalcemia was transient or permanent. Results: The 142 patients consisted of 23 males (16.2%) and 119 females (83.8%). The mean age was 49.5 years. The surgery performed was bilateral total thyroidectomy in 131, bilateral subtotal thyroidectomy in 3, left total right subtotal thyroidectomy in 3, right total leftsubtotalthyroidectomy in 2, left thyroid lobectomy in 2, and complementary thyroidectomy in 1. Unilateral neck dissection (level II, III, IV, V) was performed in 2 patients and central lymphnode dissection in 82 patients. Parathyroid tissue was found to have been excised during surgery in 35 patients, consisting of 33 females (94.2%) and 2 males (5.8%). The parathyroid tissue had been removed incidentally in 31 and not incidentally in 4. We found transient hypocalcemia in 42 patients and permanent hypocalcemia in 2 patients. Discussion: We found that some parathyroid glands had been inadvertently removed despite careful thyroid surgery. We believe that checking the PTH level postoperatively is important in determining hypocalcemia. Conclusion:
{"title":"Evaluation of patients who have undergone unintentional parathyroidectomy following thyroidectomy: a retrospective cohort study -","authors":"T. Allahverdi, Harun Bayram, Kenan Binnetoğlu, T. Anuk, U. Bulut","doi":"10.5455/JTOMC.2018.01.024","DOIUrl":"https://doi.org/10.5455/JTOMC.2018.01.024","url":null,"abstract":"Aim: We investigated the postoperative parathormone levels and the incidence of hypocalcemia in patients who had inadvertently underwent parathyroidectomy during thyroid surgery . Material and Methods: We retrospectively evaluated a total of 142 patients who had undergone thyroidectomy between January 2011 and March 2017 from their charts. The demographic feature sand pathology diagnoses of the thyroidectomy patients were evaluated. The number of excised parathyroid glands in the pathology specimens and their location were determined. The PTH level was checked after surgery. Calcium was measured on the 2nd day. Calcium replacement was provided for patients with low PTH and calcium. The level of calcium replacement was determined by referring to biochemical values. Following discharge, the calcium and PTH levels were checked during outpatient visits to determine whether the hypocalcemia was transient or permanent. Results: The 142 patients consisted of 23 males (16.2%) and 119 females (83.8%). The mean age was 49.5 years. The surgery performed was bilateral total thyroidectomy in 131, bilateral subtotal thyroidectomy in 3, left total right subtotal thyroidectomy in 3, right total leftsubtotalthyroidectomy in 2, left thyroid lobectomy in 2, and complementary thyroidectomy in 1. Unilateral neck dissection (level II, III, IV, V) was performed in 2 patients and central lymphnode dissection in 82 patients. Parathyroid tissue was found to have been excised during surgery in 35 patients, consisting of 33 females (94.2%) and 2 males (5.8%). The parathyroid tissue had been removed incidentally in 31 and not incidentally in 4. We found transient hypocalcemia in 42 patients and permanent hypocalcemia in 2 patients. Discussion: We found that some parathyroid glands had been inadvertently removed despite careful thyroid surgery. We believe that checking the PTH level postoperatively is important in determining hypocalcemia. Conclusion:","PeriodicalId":17427,"journal":{"name":"Journal of Turgut Ozal Medical Center","volume":"68 1","pages":"225-227"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82417165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.5455/jtomc.2018.01.014
M. Erdogan, H. Çiftçi
Aim: Chronic renal failure is a prevalent health disorder in which risk for cardiovascular disease is increased. Cardiovascular diseases (CVDs) are one of the leading causes of mortality in this patient population. Aortic stiffness is an early and independent marker for CVDs. We aimed to investigate aortic stiffness in patients with end-stage renal disease (ESRD). Material and Methods: This study was conducted on patients who underwent hemodialysis with ESRD in Hemodialysis Unit of Nephrology Department of Goztepe Teaching Hospital between July, 2009 and November, 2009. The study included 65 patients with ESRD and 20 healthy controls. Systolic and diastolic functions of left ventricle, aortic stiffness and TEI index were evaluated in all subjects by using echocardiography. Results: Systolic and diastolic blood pressures were higher in the patient group compared to the control group (p<0.05). Having compared the patient and control groups, it was found that diastolic ventricular functions and TEI index were significantly impaired in the patient group. The aortic strain and distensibility were decreased while aortic stiffness index was increased in the patient group compared to the control group (p<0.05). Conclusion: We observed impaired cardiac functions , increased aortic stiffness and myocardial performance index (MPI) in patients with ESRD. However, we believe that this area needs more study.
{"title":"Assessment of aortic stiffness, myocardial performance index and cardiac functions in patients with end-stage renal disease","authors":"M. Erdogan, H. Çiftçi","doi":"10.5455/jtomc.2018.01.014","DOIUrl":"https://doi.org/10.5455/jtomc.2018.01.014","url":null,"abstract":"Aim: Chronic renal failure is a prevalent health disorder in which risk for cardiovascular disease is increased. Cardiovascular diseases (CVDs) are one of the leading causes of mortality in this patient population. Aortic stiffness is an early and independent marker for CVDs. We aimed to investigate aortic stiffness in patients with end-stage renal disease (ESRD). Material and Methods: This study was conducted on patients who underwent hemodialysis with ESRD in Hemodialysis Unit of Nephrology Department of Goztepe Teaching Hospital between July, 2009 and November, 2009. The study included 65 patients with ESRD and 20 healthy controls. Systolic and diastolic functions of left ventricle, aortic stiffness and TEI index were evaluated in all subjects by using echocardiography. Results: Systolic and diastolic blood pressures were higher in the patient group compared to the control group (p<0.05). Having compared the patient and control groups, it was found that diastolic ventricular functions and TEI index were significantly impaired in the patient group. The aortic strain and distensibility were decreased while aortic stiffness index was increased in the patient group compared to the control group (p<0.05). Conclusion: We observed impaired cardiac functions , increased aortic stiffness and myocardial performance index (MPI) in patients with ESRD. However, we believe that this area needs more study.","PeriodicalId":17427,"journal":{"name":"Journal of Turgut Ozal Medical Center","volume":"91 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83950096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.5455/JTOMC.2017.12.151
H. Onder, G. Kanyilmaz, M. Aktan, E. Karahacioǧlu
Aim: To investigate survival results of patients with low grade gliomas (LGGs) and to evaluate the predictive role of clinico-pathologic prognostic factors on survival. Material and Methods: Between 2003 and 2014, the adult patients with Grade II glial tumors were evaluated retrospectively. Several variables were investigated to find prognostic factors related to the overall survival (OS) and progression-free survival (PFS). Results: This study involved 124 patients with median 40 (range; 6-132) months follow up. Patients with low pignatti risk score had a longer OS than high pignatti risk score (p=0.01). Patients with seizure had a better OS (p=0.03). Patients with biopsy/partial resection had a poorer OS (p=0.02). Patients with residue after initial surgery had a worse OS (p=0.03). The patients with recurrence or progression had poorer OS (p=0.01). Tumor with malignant transformation (p=0.01) and glioblastoma subtype after second surgery (p=0.003) had a poorer OS. The Pignatti risk score and seizure were the independent prognostic factors for PFS. Conclusion: The extent of surgery and recurrence or progression of Grade II glioma were the independent prognostic factors for OS. The Pignatti risk score and seizure were the independent prognostic factors for PFS.
{"title":"Prognostic factors for survival in adult patients with grade II glial tumors","authors":"H. Onder, G. Kanyilmaz, M. Aktan, E. Karahacioǧlu","doi":"10.5455/JTOMC.2017.12.151","DOIUrl":"https://doi.org/10.5455/JTOMC.2017.12.151","url":null,"abstract":"Aim: To investigate survival results of patients with low grade gliomas (LGGs) and to evaluate the predictive role of clinico-pathologic prognostic factors on survival. Material and Methods: Between 2003 and 2014, the adult patients with Grade II glial tumors were evaluated retrospectively. Several variables were investigated to find prognostic factors related to the overall survival (OS) and progression-free survival (PFS). Results: This study involved 124 patients with median 40 (range; 6-132) months follow up. Patients with low pignatti risk score had a longer OS than high pignatti risk score (p=0.01). Patients with seizure had a better OS (p=0.03). Patients with biopsy/partial resection had a poorer OS (p=0.02). Patients with residue after initial surgery had a worse OS (p=0.03). The patients with recurrence or progression had poorer OS (p=0.01). Tumor with malignant transformation (p=0.01) and glioblastoma subtype after second surgery (p=0.003) had a poorer OS. The Pignatti risk score and seizure were the independent prognostic factors for PFS. Conclusion: The extent of surgery and recurrence or progression of Grade II glioma were the independent prognostic factors for OS. The Pignatti risk score and seizure were the independent prognostic factors for PFS.","PeriodicalId":17427,"journal":{"name":"Journal of Turgut Ozal Medical Center","volume":"73 1","pages":"105-111"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83210805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.5455/JTOMC.2018.03.046
S. Oter, V. Oter
Aim: To examine the effect of erythropoetin on renal function and histological findings in experimental septic shock model, 24 Sprague-Dawley rats were used. Material and Methods: Rats were divided into control, septic shock, and erythropoetin-treated septic shock groups. Femoral vein and artery catheterization were performed on all rats. Rats in the control group underwent laparotomy and catheterization; in the test groups, cecal ligation-perforation and bladder cannulation were added. Rats in the treatment group received a single intraperitoneal (IP) injection of 250 mg/kg erythropoetin 60 minutes after cecal ligation perforation. Rats were monitored for blood pressure, heart rate, and body temperature to assess the postoperative septic response. The body fluids were replaced as necessary. At the end of 24 hours, rats were sacrificed and renal samples were collected. Results: In our study, although there were lessstudies about septic shock model with erythropoietin, we have achieved similar results as the data in the available literatures. WBC, fever, urinary volume, urinary creatinin, BUN, blood creatinin values were significantly better in sepsis treated by erythropoietin group than non-treated sepsis group (p<0,001, table 1)Significant improvements were observed in histological findings in rats treated with erythropoetin, compared to rats with untreated. Discussion: Our findings demonstrate that erythropoetin has antioxidant effects of sepsis as seen in other studies. We conclude that erythropoetin may be an effective treatment for oxidative damage due to renal tissue perfusion defects in cases of septic shock.
{"title":"Effects of erythropoietin on renal tissue in an experimental rat model of septic shock","authors":"S. Oter, V. Oter","doi":"10.5455/JTOMC.2018.03.046","DOIUrl":"https://doi.org/10.5455/JTOMC.2018.03.046","url":null,"abstract":"Aim: To examine the effect of erythropoetin on renal function and histological findings in experimental septic shock model, 24 Sprague-Dawley rats were used. Material and Methods: Rats were divided into control, septic shock, and erythropoetin-treated septic shock groups. Femoral vein and artery catheterization were performed on all rats. Rats in the control group underwent laparotomy and catheterization; in the test groups, cecal ligation-perforation and bladder cannulation were added. Rats in the treatment group received a single intraperitoneal (IP) injection of 250 mg/kg erythropoetin 60 minutes after cecal ligation perforation. Rats were monitored for blood pressure, heart rate, and body temperature to assess the postoperative septic response. The body fluids were replaced as necessary. At the end of 24 hours, rats were sacrificed and renal samples were collected. Results: In our study, although there were lessstudies about septic shock model with erythropoietin, we have achieved similar results as the data in the available literatures. WBC, fever, urinary volume, urinary creatinin, BUN, blood creatinin values were significantly better in sepsis treated by erythropoietin group than non-treated sepsis group (p<0,001, table 1)Significant improvements were observed in histological findings in rats treated with erythropoetin, compared to rats with untreated. Discussion: Our findings demonstrate that erythropoetin has antioxidant effects of sepsis as seen in other studies. We conclude that erythropoetin may be an effective treatment for oxidative damage due to renal tissue perfusion defects in cases of septic shock.","PeriodicalId":17427,"journal":{"name":"Journal of Turgut Ozal Medical Center","volume":"1 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89895215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.5455/JTOMC.2018.04.063
N. Karaarslan, I. Yilmaz, D. Sirin, D. Baykiz, A. Demirkıran, O. Ates
Aim: Nimodipine is used to prevent cerebrovascular-originated ischemic neurological deficits, yet its effects on nucleus pulposus (NP) cells or annulus fibrosus (AF) cells weren’t studied. This study aimed to examine nimodipine’s effects on vitality and proliferation of chondroadherin (CHAD), type II collagen (COL2A1), and hypoxia-inducible factor 1 alpha (HIF 1α) gene expression in human primary NP/AF cells. Material and Methods: NP/AF cell cultures obtained from 6 patients who underwent microdiscectomy were treated with 100 µMolar nimodipine and analyzed at 0, 24, and 48 h. Data were evaluated using one-way ANOVA and post-hoc Tukey HSD with 95% confidence interval. Results: We observed suppressed cell proliferation and increased necrosis in nimodipine-treated NP/AF cell cultures, especially degenerated tissue. COL2A1 gene expression wasn’t detected in any experimental groups. CHAD and HIF 1α expression had time-dependent decreases in control. CHAD and HIF 1α expression were found to decrease at 24h, but increased at 48h in degenerated tissue. In nimodipine-applied intact tissues, CHAD expression was stable at 24h but 1.62 times higher than control at 48h. HIF 1α levels were lower than control. Conclusion: In nimodipine-treated degenerated AF/NP cultures, CHAD and HIF 1α expressions had time-dependent decreases. However, after complete RT-PCR data evaluation, no correlation between nimodipine application and gene expression occurred.
{"title":"Do we damage nucleus pulposus tissue while treating cerebrovascular ischemic neurological deficits with nimodipine","authors":"N. Karaarslan, I. Yilmaz, D. Sirin, D. Baykiz, A. Demirkıran, O. Ates","doi":"10.5455/JTOMC.2018.04.063","DOIUrl":"https://doi.org/10.5455/JTOMC.2018.04.063","url":null,"abstract":"Aim: Nimodipine is used to prevent cerebrovascular-originated ischemic neurological deficits, yet its effects on nucleus pulposus (NP) cells or annulus fibrosus (AF) cells weren’t studied. This study aimed to examine nimodipine’s effects on vitality and proliferation of chondroadherin (CHAD), type II collagen (COL2A1), and hypoxia-inducible factor 1 alpha (HIF 1α) gene expression in human primary NP/AF cells. Material and Methods: NP/AF cell cultures obtained from 6 patients who underwent microdiscectomy were treated with 100 µMolar nimodipine and analyzed at 0, 24, and 48 h. Data were evaluated using one-way ANOVA and post-hoc Tukey HSD with 95% confidence interval. Results: We observed suppressed cell proliferation and increased necrosis in nimodipine-treated NP/AF cell cultures, especially degenerated tissue. COL2A1 gene expression wasn’t detected in any experimental groups. CHAD and HIF 1α expression had time-dependent decreases in control. CHAD and HIF 1α expression were found to decrease at 24h, but increased at 48h in degenerated tissue. In nimodipine-applied intact tissues, CHAD expression was stable at 24h but 1.62 times higher than control at 48h. HIF 1α levels were lower than control. Conclusion: In nimodipine-treated degenerated AF/NP cultures, CHAD and HIF 1α expressions had time-dependent decreases. However, after complete RT-PCR data evaluation, no correlation between nimodipine application and gene expression occurred.","PeriodicalId":17427,"journal":{"name":"Journal of Turgut Ozal Medical Center","volume":"71 1","pages":"266-273"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90952500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.5455/JTOMC.2018.01.03
Ç. C. Türer, A. Türer, Gamze Altun
Aim: Periodontitis is a chronic inflammatory disease characterized by tissue destruction. Patients with diabetes mellitus are more susceptible to severe tissue destruction. Puerarin, a biological component derived from Pueraria lobate, has anti-inflammatory and anti-diabetic effects. The purpose of the study is to evaluate the protective role of puerarin on alveolar bone loss and connective tissue destruction in ligature induced diabetic and non-diabetic rats. Material and methods: Sixty rats were divided as non-diabetic control, non-diabetic-experimental periodontitis (EP)-systemic saline, non-diabetic-EP-systemic puerarin, diabetic control, diabetic-EP-systemic saline and diabetic-EP-systemic puerarin. Diabetes was induced by injection of streptozocin (200 mg/kg). EP was achieved by placing a sterile silk suture around the first molars into the gingival sulcus for 15 days. In puerarin treated groups, 200 mg/kg puerarin was applied daily for 15 days beginning one-day prior the placement of the ligature. The alveolar bone level of the first molar tooth, alveolar bone ratio in the furcation area and the attachment level were evaluated histologically. MMP-9, TIMP-1 levels and RANKL/OPG ratio were evaluated immunohistochemically. Results: Significantreduced alveolar bone and attachment losses were found in puerarin-treated groups comparing to in saline-administered groups (p
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