{"title":"Clinicopathological Spectrum of Pancytopenia in Tertiary Care Centre in Northern India","authors":"K. Patiri","doi":"10.24321/2454.8642.201810","DOIUrl":null,"url":null,"abstract":"Introduction: The term pancytopenia refers to a reduction in all three formed elements of blood-erythrocytes, leucocytes and platelets. It is not a disease entity, but rather a triad of findings that may result from a number of disease processes. The causes of pancytopenia vary depending on multiple factors. This prospective study was conducted to find out various causes of pancytopenia and their relative frequencies in a tertiary care hospital in northern India. Methods: In the present study, 60 cases were taken up for a period of 2 years at a tertiary care hospital in Northern India. The study was composed of a brief work up of history, general and systemic examination and complete hematological work up. All the data was compiled and a final diagnosis was made. Results: The age of the patients varied from 6 months to 70 years consisting of 34 males (57%) and 26 females (43%). Megaloblastic anemia was the most common cause (66.7%) followed by aplastic anemia (19%) and malignancies (6.7%). Infections and parasitic infestations accounted for the rest. Conclusion: In our study, more than 50% of the cases are due to megaloblastic anemia prevalent due to dietary deficiency & malnutrition. Also, infections and infestations (Tuberculosis, malaria, kalaazar and typhoid) should be kept in mind as a differential diagnosis of pancytopenia.","PeriodicalId":20962,"journal":{"name":"Recent Advances in Pathology & Laboratory Medicine","volume":"34 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Recent Advances in Pathology & Laboratory Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24321/2454.8642.201810","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Introduction: The term pancytopenia refers to a reduction in all three formed elements of blood-erythrocytes, leucocytes and platelets. It is not a disease entity, but rather a triad of findings that may result from a number of disease processes. The causes of pancytopenia vary depending on multiple factors. This prospective study was conducted to find out various causes of pancytopenia and their relative frequencies in a tertiary care hospital in northern India. Methods: In the present study, 60 cases were taken up for a period of 2 years at a tertiary care hospital in Northern India. The study was composed of a brief work up of history, general and systemic examination and complete hematological work up. All the data was compiled and a final diagnosis was made. Results: The age of the patients varied from 6 months to 70 years consisting of 34 males (57%) and 26 females (43%). Megaloblastic anemia was the most common cause (66.7%) followed by aplastic anemia (19%) and malignancies (6.7%). Infections and parasitic infestations accounted for the rest. Conclusion: In our study, more than 50% of the cases are due to megaloblastic anemia prevalent due to dietary deficiency & malnutrition. Also, infections and infestations (Tuberculosis, malaria, kalaazar and typhoid) should be kept in mind as a differential diagnosis of pancytopenia.