Analysis of clinical and epidemiological indicators of peripheral artery disease in patients living in close vicinity of uranium legacy sites

Abstract

The article presents results of clinical and epidemiological analysis of medical records of patients lived in the vicinity of uranium legacy sites and suffered from peripheral artery disease. The rec-ords of 474 patients were examined, 40 of the patients were included in the main group. The con-trol groups 1 and 2 contained 434 patients lived in conditionally "clean" sites, free of waste de-posited in low and middle altitude sites. The results demonstrate prevalence of multilevel occlu-sive lesions of the arteries of the lower extremities group with involvement in the pathological process and distal segments of the vessels (OR=6.26; 2=24.92 and OR=5.56; 2=16.7; p<0.001) in patients of the main group. The higher frequency of critical lower limb ischemia in the main group compared to the control group 2 by 1.42 times (p>0.05) indirectly points to the exertion of altitude adaptation mechanisms in patients living in radionuclide-free (OR=5.38; 2=14.22; p<0.001) and manifestations of chronic ischemia (p>0.05) in the main group exceeded the num-ber in other groups under study allows making suggestion that there were lesions on arterial walls in the main group patients. Femoral-anterior-tibial bypass surgery was implemented more frequently (OR=2.73, 2=5.49, p=0.02; OR=5.35, 2=9.09, p=0.003) in patients of the main group, this fact can be considered as the further confirmation of the presence of damage to the distal parts of the vessels. Based on the study analysis, one can draw conclusion that peripheral artery disease had specific pathogenesis and clinical features in the patients lived in the vicinity of radi-oactive waste storage sites with standard levels of radiation background and mountain climate.