Upper-lower limb and breathing exercise program for improving sleep quality and psychological status in multiple sclerosis: a pilot randomized controlled trial.

IF 1.1 4区医学 Q4 CLINICAL NEUROLOGY Brain Impairment Pub Date : 2023-03-01 Epub Date: 2021-10-01 DOI:10.1017/BrImp.2021.17

Tanja Grubić Kezele, Zrinka Trope, Valentina Ahel, Natali Ružić, Hrvoje Omrčen, Luka Đudarić, Ariana Fužinac-Smojver

{"title":"Upper-lower limb and breathing exercise program for improving sleep quality and psychological status in multiple sclerosis: a pilot randomized controlled trial.","authors":"Tanja Grubić Kezele, Zrinka Trope, Valentina Ahel, Natali Ružić, Hrvoje Omrčen, Luka Đudarić, Ariana Fužinac-Smojver","doi":"10.1017/BrImp.2021.17","DOIUrl":null,"url":null,"abstract":"Purpose: To examine the feasibility and possible effect of an 8-week exercise program on sleep quality, insomnia and psychological distress in individuals with multiple sclerosis (MS).Methods: Twenty-four individuals with MS were recruited into a controlled pre-post feasibility study and divided into 2 groups: exercise (n = 13; Expanded Disability Status Scale (EDSS): 1.0-7.5) and a related control group with no exercise (n = 11; EDSS: 1.0-7.0). The exercise group performed combined upper limb, lower limb and breathing exercises in a controlled group (2d/week, 60 min/session) for 8 weeks. Participants were administered measures to evaluate sleep quality (Pittsburgh Sleep Quality Index, PSQI), insomnia severity (Insomnia Severity Index, ISI), psychological distress (Clinical Outcomes in Routine Evaluation-Outcome Measure, CORE-OM) and additionally impact of fatigue (Modified Fatigue Impact Scale, MFIS) after 8-weeks.Results: Insomnia severity measured with ISI (F(1;22)=5.95, p = 0.023, η p 2 = 0.213, 90% CI = 0.02-0.42) and psychological distress measured with the CORE-OM (F(1;22)=4.82, p = 0.039, η p 2 = 0.179, 90% CI = 0.01-0.40) showed statistically significant group-by-time interaction. Sleep quality measured with the PSQI showed statistically significant group-by-time interaction only in an aspect of daytime sleep dysfunction (F(1;22)=5.33, p = 0.031, η p 2 = 0.195, 90% CI = 0.01-0.40). The fatigue impact measured with the MFIS showed statistically significant group-by-time interaction in physical (F(1;22)=6.80, p = 0.016, η p 2 = 0.236, 90% CI = 0.02-0.44) and cognitive aspects (F(1;22)=9.12, p = 0.006, η p 2 = 0.293, 90% CI = 0.05-0.49), and total score (F(1;22)=11.29, p = 0.003, η p 2 = 0.339, 90% CI = 0.08-0.52).Conclusions: Our 8-week program reduced insomnia severity, psychological distress and some aspects of fatigue (physical; cognitive; total), and improved sleep quality in an aspect of daytime sleep dysfunction in a small group of individuals with MS. Good feasibility and significant positive changes from baseline warrant further exploratory work.","PeriodicalId":56329,"journal":{"name":"Brain Impairment","volume":null,"pages":null},"PeriodicalIF":1.1000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Impairment","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/BrImp.2021.17","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/10/1 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: To examine the feasibility and possible effect of an 8-week exercise program on sleep quality, insomnia and psychological distress in individuals with multiple sclerosis (MS).

Methods: Twenty-four individuals with MS were recruited into a controlled pre-post feasibility study and divided into 2 groups: exercise (n = 13; Expanded Disability Status Scale (EDSS): 1.0-7.5) and a related control group with no exercise (n = 11; EDSS: 1.0-7.0). The exercise group performed combined upper limb, lower limb and breathing exercises in a controlled group (2d/week, 60 min/session) for 8 weeks. Participants were administered measures to evaluate sleep quality (Pittsburgh Sleep Quality Index, PSQI), insomnia severity (Insomnia Severity Index, ISI), psychological distress (Clinical Outcomes in Routine Evaluation-Outcome Measure, CORE-OM) and additionally impact of fatigue (Modified Fatigue Impact Scale, MFIS) after 8-weeks.

Results: Insomnia severity measured with ISI (F(1;22)=5.95, p = 0.023, η _p ² = 0.213, 90% CI = 0.02-0.42) and psychological distress measured with the CORE-OM (F(1;22)=4.82, p = 0.039, η _p ² = 0.179, 90% CI = 0.01-0.40) showed statistically significant group-by-time interaction. Sleep quality measured with the PSQI showed statistically significant group-by-time interaction only in an aspect of daytime sleep dysfunction (F(1;22)=5.33, p = 0.031, η _p ² = 0.195, 90% CI = 0.01-0.40). The fatigue impact measured with the MFIS showed statistically significant group-by-time interaction in physical (F(1;22)=6.80, p = 0.016, η _p ² = 0.236, 90% CI = 0.02-0.44) and cognitive aspects (F(1;22)=9.12, p = 0.006, η _p ² = 0.293, 90% CI = 0.05-0.49), and total score (F(1;22)=11.29, p = 0.003, η _p ² = 0.339, 90% CI = 0.08-0.52).

Conclusions: Our 8-week program reduced insomnia severity, psychological distress and some aspects of fatigue (physical; cognitive; total), and improved sleep quality in an aspect of daytime sleep dysfunction in a small group of individuals with MS. Good feasibility and significant positive changes from baseline warrant further exploratory work.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

改善多发性硬化症患者睡眠质量和心理状态的上下肢和呼吸锻炼计划：随机对照试验。

目的：研究为期8周的锻炼计划对多发性硬化症（MS）患者的睡眠质量、失眠和心理困扰的可行性和可能影响：方法：24 名多发性硬化症患者被招募参加一项前后对照可行性研究，并被分为两组：运动组（n = 13；残疾状况扩展量表（EDSS）：1.0-7.5）和失眠组（n = 10；残疾状况扩展量表（EDSS）：1.0-7.5）：1.0-7.5）和不做运动的相关对照组（n = 11；EDSS：1.0-7.0）。锻炼组在对照组中进行上肢、下肢和呼吸综合锻炼（每周 2 次，每次 60 分钟），为期 8 周。8 周后，对参与者进行睡眠质量（匹兹堡睡眠质量指数，PSQI）、失眠严重程度（失眠严重程度指数，ISI）、心理困扰（常规评估中的临床结果-结果测量，CORE-OM）和疲劳影响（改良疲劳影响量表，MFIS）的评估：用 ISI 测量的失眠严重程度（F(1;22)=5.95, p = 0.023, η p 2 = 0.213, 90% CI = 0.02-0.42）和用 CORE-OM 测量的心理压力（F(1;22)=4.82, p = 0.039, η p 2 = 0.179, 90% CI = 0.01-0.40）显示出显著的组间时间交互作用。用 PSQI 测量的睡眠质量仅在日间睡眠功能障碍方面显示出具有统计学意义的组间交互作用（F(1;22)=5.33, p = 0.031, η p 2 = 0.195, 90% CI = 0.01-0.40）。在身体（F（1；22）=6.80，p = 0.016，η p 2 = 0.236，90% CI = 0.02-0.44）和认知方面（F(1;22)=9.12, p = 0.006, η p 2 = 0.293, 90% CI = 0.05-0.49），以及总分（F(1;22)=11.29, p = 0.003, η p 2 = 0.339, 90% CI = 0.08-0.52）：我们为期8周的计划降低了失眠的严重程度、心理压力和疲劳的某些方面（身体、认知、总体），并改善了一小部分多发性硬化症患者白天睡眠功能障碍方面的睡眠质量。良好的可行性和与基线相比的显著积极变化值得进一步探索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Brain Impairment CLINICAL NEUROLOGY-NEUROSCIENCES

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The journal addresses topics related to the aetiology, epidemiology, treatment and outcomes of brain impairment with a particular focus on the implications for functional status, participation, rehabilitation and quality of life. Disciplines reflect a broad multidisciplinary scope and include neuroscience, neurology, neuropsychology, psychiatry, clinical psychology, occupational therapy, physiotherapy, speech pathology, social work, and nursing. Submissions are welcome across the full range of conditions that affect brain function (stroke, tumour, progressive neurological illnesses, dementia, traumatic brain injury, epilepsy, etc.) throughout the lifespan.