A retrospective study evaluating the pretreatment tumor volume (PTV) in non-small cell lung cancer (NSCLC) as a predictor of response to program death-1 (PD-1) inhibitors

IF 5.1 Q1 ONCOLOGY Lung Cancer: Targets and Therapy Pub Date : 2019-09-12 DOI:10.2147/LCTT.S219886
M. Nagasaka, Nadine H Abdallah, Marcus Crosby, Nithin Thummala, Dhaval Patel, A. Wozniak, S. Gadgeel, J. Abrams, A. Sukari
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引用次数: 4

Abstract

Introduction of hypothesis Little information is available regarding the imaging characteristics that assist in differentiating responders from non-responders. We hypothesized that patients with higher pretreatment tumor volume (PTV) would have lower response rates and shorter overall survival (OS). Methods Data from patients who received at least one dose of program death-1 (PD-1) inhibitors before August 31, 2016 were captured from our institution’s pharmacy database. The primary objective was to determine the association of PTV with best response, evaluated utilizing RECIST v1.1 criteria. Secondary objectives were estimation of progression-free survival (PFS) and OS. PTV was measured using the Philips Intellispace Multi-Modality Tumor Tracking application. Results 116 non-small cell lung cancer (NSCLC) patients were evaluated. 66% patients had adenocarcinoma, 28% had squamous cell carcinoma and 5% had poorly differentiated NSCLC. Median PTV was 53.7 cm3 (95% CI: 13.3–107.9). Only one individual had no metastases and the remainder had M1 disease; 38% M1a, 10% M1b, 51% M1c. Most (79%) were previously treated. There were no complete responses; among those followed for at least 6 weeks, 26% had a partial response, 39% stable disease and 34% PD; 4% had no recorded response. There were no strong associations of PTV with any of the demographic or clinical characteristics. There was no association between PTV and OS (HR 1.2, P=0.26) or PFS (HR 1.1, P=0.47). Liver metastasis was associated with shorter survival (HR=2.8, P=0.05). Conclusion PTV in NSCLC did not prove to be a predictor of response to PD-1 inhibitors but having liver metastasis was associated with significantly shorter survival.
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一项评估非小细胞肺癌(NSCLC)预处理肿瘤体积(PTV)作为对程序性死亡-1 (PD-1)抑制剂反应的预测因子的回顾性研究
关于有助于区分反应者和非反应者的成像特征的信息很少。我们假设预处理肿瘤体积(PTV)较高的患者应答率较低,总生存期(OS)较短。方法从我院药学数据库中获取2016年8月31日前接受至少一剂PD-1抑制剂治疗的患者数据。主要目的是确定PTV与最佳反应的关系,使用RECIST v1.1标准进行评估。次要目标是估计无进展生存期(PFS)和OS。PTV使用Philips Intellispace多模态肿瘤跟踪应用程序测量。结果对116例非小细胞肺癌(NSCLC)患者进行了评价。66%患者为腺癌,28%为鳞状细胞癌,5%为低分化非小细胞肺癌。中位PTV为53.7 cm3 (95% CI: 13.3-107.9)。只有一个人没有转移,其余的人有M1疾病;38% M1a, 10% M1b, 51% M1c。大多数(79%)以前接受过治疗。没有完整的反应;在随访至少6周的患者中,26%部分缓解,39%病情稳定,34% PD;4%的患者无应答记录。PTV与任何人口统计学或临床特征没有很强的联系。PTV与OS (HR 1.2, P=0.26)或PFS (HR 1.1, P=0.47)无相关性。肝转移患者的生存期较短(HR=2.8, P=0.05)。结论非小细胞肺癌的PTV并不能预测PD-1抑制剂的疗效,但肝转移与较短的生存期相关。
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来源期刊
CiteScore
8.10
自引率
0.00%
发文量
10
审稿时长
16 weeks
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