Magnesium Zinc Oxide Nanostructure-modified Quartz Crystal Microbalance for Dynamic Monitoring of Antibiotic Effects and Antimicrobial Resistance

Procedia Technology Pub Date : 2017-01-01 DOI:10.1016/j.protcy.2017.04.022

Pavel Ivanoff Reyes , Keyang Yang , Andrew Zheng , Rui Li , Guangyuan Li , Yicheng Lu , Chi Kwan Tsang , Steven X.F. Zheng

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引用次数: 3

Abstract

We demonstrate a magnesium zinc oxide (MZO) nanostructure-modified quartz crystal microbalance (MZO_nano-QCM) biosensor to dynamically monitor antimicrobial effects on E. coli and S. cerevisiae. The MZO nanostructures were grown on the top electrode of a standard QCM using metal-organic chemical-vapor deposition (MOCVD). The MZO nanostructures are utilized as the sensing material due to their multifunctionality, biocompatibility, and very large effective sensing surface. The MZO surface-wettability and morphology are controlled, offering high-sensitivity to various biological/biochemical species. The MZO_nano-QCM was applied to detect the effects of ampicillin and tetracycline on sensitive and resistant strains of E.coli, as well as effects of amphotericin-B and miconazole on S. cerevisiae through the device's time-dependent frequency shift and motional resistance.

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氧化镁锌纳米结构修饰石英晶体微天平用于抗生素效应和耐药性动态监测

我们展示了一种氧化镁锌(MZO)纳米结构修饰的石英晶体微天平(mzono - qcm)生物传感器，用于动态监测对大肠杆菌和酿酒葡萄球菌的抗菌作用。采用金属有机化学气相沉积法(MOCVD)在标准QCM的顶电极上生长MZO纳米结构。MZO纳米结构由于其多功能性、生物相容性和非常大的有效传感表面而被用作传感材料。MZO的表面润湿性和形态是可控的，对各种生物/生化物质具有高灵敏度。利用mzono - qcm检测氨苄西林和四环素对大肠杆菌敏感和耐药菌株的影响，以及两性霉素- b和咪康唑对葡萄球菌的影响。

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Procedia Technology

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