Clinical case of pseudomembranous colitis in a patient with post-COVID syndrome

Abstract

Patients with COVID-19 most often have severe respiratory diseases, while about 19% of patients with COVID-19 exhibit gastrointestinal disorders. Excessive use of antibacterial drugs increases the risk of changes in the microbiota, the appearance of diarrhea and infection with Clostridioides difficile (CDI). Clostridium difficile infection (CDI) is a severe infectious disease of the colon caused by an obligate anaerobic organism releasing two main exotoxins: toxin A (TcdA) and toxin B (TcdB), which cause CDI symptoms: intestinal damage and inflammation of the mucous membrane, which leads to a serious complication – pseudomembranous colitis. This disease is difficult to treat and may cause a relapse. That is why emphasis is currently being put on the prevention of this disease.