The Effect of Antipsychotic Drugs on Salivary Flow Rate and Dental Caries in Schizophrenic Patients

Abstract

- This study sought to ascertain how antipsychotics affected patients with schizophrenia's salivary flow and risk of dental caries. 24 individuals with recently diagnosed schizophrenia who were given antipsychotic medication by a licensed psychiatrist made up the study population. Patients with schizophrenia who are on first-generation antipsychotic medications make up 12 participants, while patients with schizophrenia who are taking second-generation antipsychotic medications make up another 12 participants. Participants' oral health status was assessed using the decay index/missing/filled teeth (DMFT) and salivary flow rate. The results of this study indicate that in the first-generation group, 50.0% of patients were hydrated for 30 to 60 seconds, 66.7% of patients had foamy or bubbly saliva, 50% of patients had a PH of 6.0 to 6.8, and the mean salivation rate was 0.13 ± 0.06 milliliters per minute. In the second-generation group B, the mean salivation rate was 0.24 ± 0.09 (ml/min), 66.7% of patients had frothy or bubbly saliva, 66.7% had saliva with a PH of 6.8–7.8, and 58.3% had hydration 30 seconds. In terms of DMFT, 41.6 and 41.7% of patients in both groups they have had DMFT 0 at day zero. The DMFT score of zero, however, rapidly reduced in the second-generation group while remaining constant in the first-generation group. At 12 months, the variations in DMFT between the two groups were statistically significant (P <0.005). In conclusion, 2nd generation drug recipients with schizophrenia had much better oral health than the 1st generation group.