Magnesium Enhances the Antidiabetic Activity of Lippia multiflora Aqueous Leaves Extract on Redox Status in Streptozotocin-diabetic Rats

Abstract

Objective: This study was conducted in order to evaluate the antioxidant effects of Lippia multiflora aqueous extract supplemented with magnesium in diabetic rats. Méthodes: 7 groups of 4 STZ-diabetic rats received separately the Glucophage® (Glu 10 mg/kg), the plant aqueous extract (LiMAE 200-600 mg/kg) and the plant aqueous extract supplemented with magnesium (LiMAE-Mg 200-600 mg/kg) in comparison to healthy rats and untreated diabetic rats. After 21 days of daily treatment, activities of enzymes-markers of oxidative stress were measured on kidney and pancreas samples. Results: The occurrence of diabetes induced a significant increase in MDA and a significant decrease in CAT, SOD and GSH in rats. Separate treatment of animals with LiMAE and LiMAE-Mg significantly restored at p < 0.0001 and in a dose-dependent manner the activities and levels of enzymes-markers of oxidative stress. This restoration was greater with LiMAE-Mg, the aqueous extract of Lippia multiflora supplemented with magnesium. LiMAE-Mg very significantly restored the studied parameters with measured values statistically close to normal. Conclusion: The results showed the antidiabetic potential of Lippia multflora extract supplemented with magnesium on oxidative stress.