Synthesis, DNA Binding, DFT Calculations and Molecular Docking Studies of Biologically
Active N-((3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)naphthyl Derivatives
{"title":"Synthesis, DNA Binding, DFT Calculations and Molecular Docking Studies of Biologically\nActive N-((3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)naphthyl Derivatives","authors":"P. Sandhya, P. R. Swaran, E. Harikrishnan","doi":"10.14233/ajomc.2022.ajomc-p389","DOIUrl":null,"url":null,"abstract":"Six novel pyrazole compounds were synthesized, characterized and its antimicrobial activity was also evaluated. In vitro antibacterial activity against diverse bacterial and fungal strains was tested and the results were compared to the standard drug. The DNA binding properties of calf thymus DNA (ct-DNA) were investigated using electronic absorption and fluorescence spectroscopies . The software performed computer-aided molecular docking experimentations on proteins and (ct-DNA). Synthesized compounds revealed moderate to satisfactory biological activities both experimentally and theoretically.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Organic & Medicinal Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14233/ajomc.2022.ajomc-p389","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Six novel pyrazole compounds were synthesized, characterized and its antimicrobial activity was also evaluated. In vitro antibacterial activity against diverse bacterial and fungal strains was tested and the results were compared to the standard drug. The DNA binding properties of calf thymus DNA (ct-DNA) were investigated using electronic absorption and fluorescence spectroscopies . The software performed computer-aided molecular docking experimentations on proteins and (ct-DNA). Synthesized compounds revealed moderate to satisfactory biological activities both experimentally and theoretically.