APPLICATION OF CURCUMINOIDS-LOADED NANOEMULSION FOR CANCER THERAPY

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2022-12-13 DOI:10.31069/japsrv5i3.04

E. Coelho, Francisco Célio Feitosa De França, Louhana Moreira Rebouças, A. Uchoa, Luana De Morais Semião, Deyse De Sousa Maia, D. Moreira, D. Pinheiro, Larissa Morais Ribeiro da Silva, C. Pessoa, M. E. Ribeiro, N. Ricardo

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Abstract

INTRODUCTION: Curcuminoids and Oleic acid, reported in the literature as antioxidant and antitumor agents, were combined in nanoemulsion, using Pluronic F127 as a stabilizer. METHODS: The main objective is to investigate its cytotoxic activity against cancer cells. RESULTS AND DISCUSSION: The nanoemulsion show values of the particle size (251.4 ± 4.6 nm), zeta potential (-34.8 ± 1.0 mV), and pH (4.8) classifying it as stable and non-irritating for pharmacological applications. The main results indicate that, in the toxicity test in fish (Zebrafish), the nanoformulation proved to be biosafe and the evaluation of the antioxidant action (by DPPH) showed excellent antioxidant activity. Furthermore, in the vitro cytotoxicity studies, the nanoemulsions showed good cytotoxic activity, ideal for fighting Colorectal, Glioblastoma, and Leukemia cancers and more effectively in Prostate cancer.

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姜黄素纳米乳在肿瘤治疗中的应用

介绍:以Pluronic F127为稳定剂，将姜黄素和油酸作为抗氧化剂和抗肿瘤剂组合成纳米乳。方法:主要目的是研究其对癌细胞的细胞毒活性。结果和讨论:纳米乳的粒径(251.4±4.6 nm)、zeta电位(-34.8±1.0 mV)和pH(4.8)表明其稳定且无刺激性，可用于药理应用。主要结果表明，在鱼类(斑马鱼)的毒性试验中，纳米制剂被证明是生物安全的，抗氧化作用(DPPH)评价显示出良好的抗氧化活性。此外，在体外细胞毒性研究中，纳米乳液显示出良好的细胞毒性活性，是治疗结直肠癌、胶质母细胞瘤和白血病的理想选择，对前列腺癌更有效。

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INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH

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