Human Papillomavirus (HPV) Viral Proteins Substitute for the Impact of Somatic Mutations by Affecting Cancer-Related Genes: Meta-analysis and Perspectives

Zisheng Shang, V. Kouznetsova, I. Tsigelny
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引用次数: 3

Abstract

Purpose: Although a strong association between human papillomavirus (HPV) and a variety of cancers has long been established, infection by HPV alone has been shown to be insufficient for the induction of cancer, with a large number of HPV infections regressing without causing cancer. Additionally, HPV-negative cases have worse prognosis rates than HPV-positive ones across a multitude of cancer types. The reasons behind these phenomena are poorly understood. We try to explain it.
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人乳头瘤病毒(HPV)病毒蛋白通过影响癌症相关基因来替代体细胞突变的影响:meta分析和观点
目的:虽然人类乳头瘤病毒(HPV)与多种癌症之间的密切联系早已确立,但仅感染HPV不足以诱发癌症,大量HPV感染消退而不致癌。此外,在多种癌症类型中,hpv阴性病例的预后率比hpv阳性病例更差。人们对这些现象背后的原因知之甚少。我们试图解释它。
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