Pub Date : 2024-01-08DOI: 10.29245/2689-9981/2023/2.1173
Attinsounon Cossi Angelo, Dovonou Comlan Albert, A. Kazali, Kanninkpo Fabius, A. Adébayo, Vodounou Amos, S. Khadidjatou, Serge Adé
Introduction: Literature data suggest that people living with the human immunodeficiency virus (PLHIV) are at increased risk of severe forms of Coronavirus 2019 (COVID-19) infection and related mortality. The aim of this study was to investigate the anti-SARS-CoV-2 serological profile in adults living with HIV followed at the Departmental and Teaching Hospital of Borgou (DTH-B) in 2022 and to identify factors associated with anti-SARS-CoV-2 seropositivity in the latter. Methods: This was a descriptive and analytical cross-sectional study conducted in the Internal Medicine Department at DTH-B, from June 27, 2022 to July 27, 2022. PLHIV were systematically recruited after informed consent. A survey form was used to collect epidemiological, clinical, paraclinical and therapeutic data. Anti-SARS-CoV-2 antibodies (IgG and IgM) were tested using the BIOSYNEX COVID-19 BSS rapid test (Biosynex SA, France). Data were analyzed using STATA/MP14.1 software. The significance level was 5%. Results: A total of 135 adults living with HIV were included in the study. The sex ratio was 0.34 and the mean age 45 ± 11.03 years. Anti-SARS-CoV-2 seroprevalence was 50.37%. Only one respondent reported a confirmed COVID-19, while vaccination coverage was 37.78%. Anti-SARS-CoV-2 seroprevalence in unvaccinated patients was 40.48%. Factors significantly associated with anti-SARS-CoV-2 seropositivity in multivariate analysis were vaccination status (p=0.02) and viral load (p=0.001). Conclusion: Anti-SARS-CoV-2 antibodies were detectable in more than half the PLHIV. Their presence was associated with the notion of vaccination and an undetectable viral load. This study therefore suggests the need to promote COVID-19 vaccination among PLHIV followed up at DTH-B, as well as the continuation of adequate management of HIV infection in order to reduce COVID-19-related morbidity and mortality in this so-called vulnerable population.
{"title":"Anti-SARS-CoV2 serological profile and associated factors in adults living with HIV followed at Departmental and Teaching Hospital of Borgou in 2022.","authors":"Attinsounon Cossi Angelo, Dovonou Comlan Albert, A. Kazali, Kanninkpo Fabius, A. Adébayo, Vodounou Amos, S. Khadidjatou, Serge Adé","doi":"10.29245/2689-9981/2023/2.1173","DOIUrl":"https://doi.org/10.29245/2689-9981/2023/2.1173","url":null,"abstract":"Introduction: Literature data suggest that people living with the human immunodeficiency virus (PLHIV) are at increased risk of severe forms of Coronavirus 2019 (COVID-19) infection and related mortality. The aim of this study was to investigate the anti-SARS-CoV-2 serological profile in adults living with HIV followed at the Departmental and Teaching Hospital of Borgou (DTH-B) in 2022 and to identify factors associated with anti-SARS-CoV-2 seropositivity in the latter. Methods: This was a descriptive and analytical cross-sectional study conducted in the Internal Medicine Department at DTH-B, from June 27, 2022 to July 27, 2022. PLHIV were systematically recruited after informed consent. A survey form was used to collect epidemiological, clinical, paraclinical and therapeutic data. Anti-SARS-CoV-2 antibodies (IgG and IgM) were tested using the BIOSYNEX COVID-19 BSS rapid test (Biosynex SA, France). Data were analyzed using STATA/MP14.1 software. The significance level was 5%. Results: A total of 135 adults living with HIV were included in the study. The sex ratio was 0.34 and the mean age 45 ± 11.03 years. Anti-SARS-CoV-2 seroprevalence was 50.37%. Only one respondent reported a confirmed COVID-19, while vaccination coverage was 37.78%. Anti-SARS-CoV-2 seroprevalence in unvaccinated patients was 40.48%. Factors significantly associated with anti-SARS-CoV-2 seropositivity in multivariate analysis were vaccination status (p=0.02) and viral load (p=0.001). Conclusion: Anti-SARS-CoV-2 antibodies were detectable in more than half the PLHIV. Their presence was associated with the notion of vaccination and an undetectable viral load. This study therefore suggests the need to promote COVID-19 vaccination among PLHIV followed up at DTH-B, as well as the continuation of adequate management of HIV infection in order to reduce COVID-19-related morbidity and mortality in this so-called vulnerable population.","PeriodicalId":16100,"journal":{"name":"Journal of Infectiology","volume":"43 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140512292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-22DOI: 10.29245/2689-9981/2023/1.1170
Dr. Gyanshankar P. Mishra
Linezolid is an effective second-line anti-tuberculosis drug. However, the use of linezolid has been associated with rare adverse drug reactions (ADRs), one of which is the linezolid-associated black hairy tongue (BHT). This reaction is characterized by a black or dark brown discoloration of the tongue, which may be accompanied by a metallic or bitter taste. In this case report, we present a 19-year-old male patient who developed linezolid-associated black tongue while receiving linezolid as part of an all-oral, longer-course treatment regime for multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB). The patient's BHT was only cosmetic and resolved upon discontinuation of linezolid. This case report aims to raise awareness of this rare ADR and the importance of close monitoring and potential withdrawal of linezolid to optimize treatment outcomes.
{"title":"Linezolid-Associated Black Tongue: A Rare Adverse Drug Reaction","authors":"Dr. Gyanshankar P. Mishra","doi":"10.29245/2689-9981/2023/1.1170","DOIUrl":"https://doi.org/10.29245/2689-9981/2023/1.1170","url":null,"abstract":"Linezolid is an effective second-line anti-tuberculosis drug. However, the use of linezolid has been associated with rare adverse drug reactions (ADRs), one of which is the linezolid-associated black hairy tongue (BHT). This reaction is characterized by a black or dark brown discoloration of the tongue, which may be accompanied by a metallic or bitter taste. In this case report, we present a 19-year-old male patient who developed linezolid-associated black tongue while receiving linezolid as part of an all-oral, longer-course treatment regime for multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB). The patient's BHT was only cosmetic and resolved upon discontinuation of linezolid. This case report aims to raise awareness of this rare ADR and the importance of close monitoring and potential withdrawal of linezolid to optimize treatment outcomes.","PeriodicalId":16100,"journal":{"name":"Journal of Infectiology","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79139710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-19DOI: 10.29245/2689-9981/2022/1.1169
E. Deveze, D. Raimondeau, M. Ammi
Case report of a 73-year-old man with Mycobacterium bovis BCG supra renal saccular aortic aneurysm eight months after intravesical BCG therapy.
一例73岁男性患者在膀胱内卡介苗治疗8个月后并发牛卡介苗分枝杆菌肾囊主动脉瘤。
{"title":"Mycobacterium Bovis mycotic aneurysm of the visceral aorta after intravesical BCG therapy","authors":"E. Deveze, D. Raimondeau, M. Ammi","doi":"10.29245/2689-9981/2022/1.1169","DOIUrl":"https://doi.org/10.29245/2689-9981/2022/1.1169","url":null,"abstract":"Case report of a 73-year-old man with Mycobacterium bovis BCG supra renal saccular aortic aneurysm eight months after intravesical BCG therapy.","PeriodicalId":16100,"journal":{"name":"Journal of Infectiology","volume":"109 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79212970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-22DOI: 10.29245/2689-9981/2022/1.1166
Eman EL-Sawalhy, Priscila Bercea, Mohammad A Alkheder, M. Khadra, Wehbi Hanayni, Muna Shaaeli, Hanady Daas
COVID-19 infection can lead to severe consequences, especially among ethnic minorities. Data about COVID-19 infection outcomes in the Arab American population as a minority ethnic group compared to other racial and ethnic minorities are lacking. We conducted a retrospective observational cohort study that included 1,740 hospitalized adult patients with confirmed COVID-19 infection from March 12th, 2020, to January 30th, 2021, at a single center to compare baseline characteristics and outcomes in Arabs hospitalized with COVID-19 to patients from other ethnic groups during the same study period. Of those, we identified 320 Arab patients. We found that Arab American population suffered similar odds of complications and adverse outcomes despite having fewer risk factors for severe illness.
{"title":"COVID-19 in Arab Americans Revealed a Public Health Concern","authors":"Eman EL-Sawalhy, Priscila Bercea, Mohammad A Alkheder, M. Khadra, Wehbi Hanayni, Muna Shaaeli, Hanady Daas","doi":"10.29245/2689-9981/2022/1.1166","DOIUrl":"https://doi.org/10.29245/2689-9981/2022/1.1166","url":null,"abstract":"COVID-19 infection can lead to severe consequences, especially among ethnic minorities. Data about COVID-19 infection outcomes in the Arab American population as a minority ethnic group compared to other racial and ethnic minorities are lacking. We conducted a retrospective observational cohort study that included 1,740 hospitalized adult patients with confirmed COVID-19 infection from March 12th, 2020, to January 30th, 2021, at a single center to compare baseline characteristics and outcomes in Arabs hospitalized with COVID-19 to patients from other ethnic groups during the same study period. Of those, we identified 320 Arab patients. We found that Arab American population suffered similar odds of complications and adverse outcomes despite having fewer risk factors for severe illness.","PeriodicalId":16100,"journal":{"name":"Journal of Infectiology","volume":"138 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82847471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The COVID-19 infection has highlighted the most vulnerable patients. Indeed, COVID-19 patients suffering from another pathology including NCDs such as Arterial Hypertension (Hypertension), diabetes, cancers and respiratory diseases are paying a heavy price for this pandemic. We undertook a study in Niger to better document this comorbidity in a cross-sectional study that brought together patients hospitalized at the Niamey General Reference Hospital for COVID-19 infection and suffering from one or more NCDs. Among 273 patients hospitalized from March 19 to June 03, 2020, 34.8% had a non-communicable disease associated with COVID-19. The average age of the patients was 55 years (22 years to 94 years) and the sex ratio was 2.64 (72.5 % men and 27.5% women). Hypertension was the most represented NCD with 24.5%, followed by diabetes in 17.9% of cases, respiratory diseases 3.66% and other diseases (Heart disease, Obesity, Dyslipidemia, Gout, Chronic renal failure) with 3%. Health workers were the most affected by the disease with 38.6% of cases. The average consultation time was 3.77 days with extremes ranging from 1 to 8 days. The clinical symptoms characterizing the two main groups of patients (hypertensive and diabetic) were almost identical. It consisted mainly of cough, fever, chills, sore throat and rhinorrhea. According to the WHO clinical criteria for the severity of COVID-19, 34 patients or 16.11% were severe and 177 patients or 83% moderate. The clinical severity of the disease is significantly correlated with the patient's age (over 50 years) and the presence of an NCD associated with COVID-19. A total of 35.8% were hospitalized in intensive care in the NCD and COVID-19 group and 14.6% in the NCD group (p <0.001). The average length of patient hospitalization was 6.87 days overall, it was 7 days in intensive care. In 61.7% of cases the length of hospitalization was greater than 4 days. There was 22.1% in the NCD group and 7.3% in the just COVID-19 group (p <0.001). A total of 90.6% of registered deaths occurred in intensive care.
{"title":"COVID-19 Comorbidity and Non-Communicable Diseases (NCDs) General Reference Hospital (HGR), Niamey, Niger","authors":"Mahamane Sani Mahamane Aminou, Gbaguidi Aichatou Diawara, Migitaba Hassane Moctar, S. Rabiou, Emoud Tcholi Idrissa, Salifou Alkassoum Ibrahim, F. Adamou, Batouré Oumarou, Ocquet Sakina, B. Souleymane, Moussa Salia Amadou, Oumara Maman, Tambwe Didier, Anya Blanche, Ngozi Idemili-Aronu, Igweonu Obianuju, Dangou Jean-marie, Adéhossi Eric, Okeibunor Joseph Chukwudi, Talisuna Ambrose","doi":"10.29245/2689-9981/2021/1.1165","DOIUrl":"https://doi.org/10.29245/2689-9981/2021/1.1165","url":null,"abstract":"The COVID-19 infection has highlighted the most vulnerable patients. Indeed, COVID-19 patients suffering from another pathology including NCDs such as Arterial Hypertension (Hypertension), diabetes, cancers and respiratory diseases are paying a heavy price for this pandemic. We undertook a study in Niger to better document this comorbidity in a cross-sectional study that brought together patients hospitalized at the Niamey General Reference Hospital for COVID-19 infection and suffering from one or more NCDs. Among 273 patients hospitalized from March 19 to June 03, 2020, 34.8% had a non-communicable disease associated with COVID-19. The average age of the patients was 55 years (22 years to 94 years) and the sex ratio was 2.64 (72.5 % men and 27.5% women). Hypertension was the most represented NCD with 24.5%, followed by diabetes in 17.9% of cases, respiratory diseases 3.66% and other diseases (Heart disease, Obesity, Dyslipidemia, Gout, Chronic renal failure) with 3%. Health workers were the most affected by the disease with 38.6% of cases. The average consultation time was 3.77 days with extremes ranging from 1 to 8 days. The clinical symptoms characterizing the two main groups of patients (hypertensive and diabetic) were almost identical. It consisted mainly of cough, fever, chills, sore throat and rhinorrhea. According to the WHO clinical criteria for the severity of COVID-19, 34 patients or 16.11% were severe and 177 patients or 83% moderate. The clinical severity of the disease is significantly correlated with the patient's age (over 50 years) and the presence of an NCD associated with COVID-19. A total of 35.8% were hospitalized in intensive care in the NCD and COVID-19 group and 14.6% in the NCD group (p <0.001). The average length of patient hospitalization was 6.87 days overall, it was 7 days in intensive care. In 61.7% of cases the length of hospitalization was greater than 4 days. There was 22.1% in the NCD group and 7.3% in the just COVID-19 group (p <0.001). A total of 90.6% of registered deaths occurred in intensive care.","PeriodicalId":16100,"journal":{"name":"Journal of Infectiology","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85496373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-01DOI: 10.29245/2689-9981/2020/1.1157
Zisheng Shang, V. Kouznetsova, I. Tsigelny
Purpose: Although a strong association between human papillomavirus (HPV) and a variety of cancers has long been established, infection by HPV alone has been shown to be insufficient for the induction of cancer, with a large number of HPV infections regressing without causing cancer. Additionally, HPV-negative cases have worse prognosis rates than HPV-positive ones across a multitude of cancer types. The reasons behind these phenomena are poorly understood. We try to explain it.
{"title":"Human Papillomavirus (HPV) Viral Proteins Substitute for the Impact of Somatic Mutations by Affecting Cancer-Related Genes: Meta-analysis and Perspectives","authors":"Zisheng Shang, V. Kouznetsova, I. Tsigelny","doi":"10.29245/2689-9981/2020/1.1157","DOIUrl":"https://doi.org/10.29245/2689-9981/2020/1.1157","url":null,"abstract":"Purpose: Although a strong association between human papillomavirus (HPV) and a variety of cancers has long been established, infection by HPV alone has been shown to be insufficient for the induction of cancer, with a large number of HPV infections regressing without causing cancer. Additionally, HPV-negative cases have worse prognosis rates than HPV-positive ones across a multitude of cancer types. The reasons behind these phenomena are poorly understood. We try to explain it.","PeriodicalId":16100,"journal":{"name":"Journal of Infectiology","volume":"os-49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87248651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.29245/2689-9981/2020/1.1154
Gyanshankar P. Mishra, N. Babu
{"title":"https://www.infectiologyjournal.com/article/3/1","authors":"Gyanshankar P. Mishra, N. Babu","doi":"10.29245/2689-9981/2020/1.1154","DOIUrl":"https://doi.org/10.29245/2689-9981/2020/1.1154","url":null,"abstract":"","PeriodicalId":16100,"journal":{"name":"Journal of Infectiology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82035440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-01DOI: 10.29245/2689-9981/2019/4.1146
Gergès Rizkallah, R. Mahieux, H. Dutartre
Clinical Approaches of HIV-1/HTLV-1 Co-infection Still Keep their Mysteries Gerges Rizkallah1, Renaud Mahieux2, Hélène Dutartre2 1Faculty of Public Health, Sagesse University, Beirut, Lebanon 2Équipe oncogenèse rétrovirale, équipe labellisée «FRM», CIRI – Centre International de Recherche en Infectiologie, Univ Lyon, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR, ENS Lyon, Lyon, France
Clinical。unep / of gag hcmv感染Still Keep their Mysteries Gerges Rizkallah1、Renaud Mahieux2海伦Dutartre2 1Faculty大学公共健康、智慧、贝鲁特、黎巴嫩2Équipe oncogenèse蛋白酶、团队-«FRM»,CIRI—抗、里昂大学国际研究中心大学(Claude Bernard里昂1 - Inserm、U1111 CNRS、UMR ENS、里昂,里昂,法国
{"title":"Clinical Approaches of HIV-1/HTLV-1 Co-infection Still Keep their Mysteries","authors":"Gergès Rizkallah, R. Mahieux, H. Dutartre","doi":"10.29245/2689-9981/2019/4.1146","DOIUrl":"https://doi.org/10.29245/2689-9981/2019/4.1146","url":null,"abstract":"Clinical Approaches of HIV-1/HTLV-1 Co-infection Still Keep their Mysteries Gerges Rizkallah1, Renaud Mahieux2, Hélène Dutartre2 1Faculty of Public Health, Sagesse University, Beirut, Lebanon 2Équipe oncogenèse rétrovirale, équipe labellisée «FRM», CIRI – Centre International de Recherche en Infectiologie, Univ Lyon, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR, ENS Lyon, Lyon, France","PeriodicalId":16100,"journal":{"name":"Journal of Infectiology","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83684292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-01DOI: 10.29245/2689-9981/2019/4.1147
D. Lokesh, K. Rajagopal, Jae-Ho Shin
Drug-resistance is a major problem globally, the number of drug-resistant bacteria has increased substantially through horizontal gene transfer. Even Mycobacterium tuberculosis are reported to have acquired antitubercular drug-resistance and named as MDR Mtb. The acquisition of immunity has not given up, here; it is needed to be a continuous procedure. Further causing the microbial adapting to a very high and larger number of drugs recognized as extreme drug and total drug-resistance. The mechanistic aspects of MDR Mtb are well understood. Nevertheless, this is not the case with Probiotic microbes such as Bifidobacterium adolescentis. Herein, we report the mechanistic aspects of antitubercular drug-resistance in this organism for the first time. This review discusses the report by a mutation that confers multi drug-resistance in Bifidobacteria.
{"title":"Multidrug Resistant Probiotics as an Alternative to Antibiotic Probiotic therapy","authors":"D. Lokesh, K. Rajagopal, Jae-Ho Shin","doi":"10.29245/2689-9981/2019/4.1147","DOIUrl":"https://doi.org/10.29245/2689-9981/2019/4.1147","url":null,"abstract":"Drug-resistance is a major problem globally, the number of drug-resistant bacteria has increased substantially through horizontal gene transfer. Even Mycobacterium tuberculosis are reported to have acquired antitubercular drug-resistance and named as MDR Mtb. The acquisition of immunity has not given up, here; it is needed to be a continuous procedure. Further causing the microbial adapting to a very high and larger number of drugs recognized as extreme drug and total drug-resistance. The mechanistic aspects of MDR Mtb are well understood. Nevertheless, this is not the case with Probiotic microbes such as Bifidobacterium adolescentis. Herein, we report the mechanistic aspects of antitubercular drug-resistance in this organism for the first time. This review discusses the report by a mutation that confers multi drug-resistance in Bifidobacteria.","PeriodicalId":16100,"journal":{"name":"Journal of Infectiology","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76064262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-01DOI: 10.29245/2689-9981/2019/4.1142
J. Rychert
Matrix-assisted laser desorption-ionization time of flight mass spectrometry (MALDI-TOF MS) is replacing traditional methods for identifying microorganisms in the clinical laboratory. This relatively simple technique overcomes many of the challenges of identifying bacteria and fungi. As the technology has evolved, the expansion of the databases containing spectra of known organisms has allowed for the identification of species with similar phenotypic, genotypic, and biochemical properties that was not previously possible. This has resulted in improvements in clinical care including improving the diagnosis of infections caused by relatively rare species and decreasing the time to diagnosis. In many cases, this leads to a reduction in the time to appropriate therapy and even a decrease in the length of hospital stays. However, it is not without its limitations. Inherent similarities between organisms and a limited number of spectra in the database can lead to poor discrimination between species, as well as misidentifications. These errors occur with relatively low frequency and can typically be overcome with supplemental testing. The adoption of MALDITOF MS in the clinical microbiology laboratory is revolutionizing infectious disease diagnosis and clinical care.
{"title":"Benefits and Limitations of MALDI-TOF Mass Spectrometry for the Identification of Microorganisms","authors":"J. Rychert","doi":"10.29245/2689-9981/2019/4.1142","DOIUrl":"https://doi.org/10.29245/2689-9981/2019/4.1142","url":null,"abstract":"Matrix-assisted laser desorption-ionization time of flight mass spectrometry (MALDI-TOF MS) is replacing traditional methods for identifying microorganisms in the clinical laboratory. This relatively simple technique overcomes many of the challenges of identifying bacteria and fungi. As the technology has evolved, the expansion of the databases containing spectra of known organisms has allowed for the identification of species with similar phenotypic, genotypic, and biochemical properties that was not previously possible. This has resulted in improvements in clinical care including improving the diagnosis of infections caused by relatively rare species and decreasing the time to diagnosis. In many cases, this leads to a reduction in the time to appropriate therapy and even a decrease in the length of hospital stays. However, it is not without its limitations. Inherent similarities between organisms and a limited number of spectra in the database can lead to poor discrimination between species, as well as misidentifications. These errors occur with relatively low frequency and can typically be overcome with supplemental testing. The adoption of MALDITOF MS in the clinical microbiology laboratory is revolutionizing infectious disease diagnosis and clinical care.","PeriodicalId":16100,"journal":{"name":"Journal of Infectiology","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82216934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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