{"title":"Effect of methanolic extract of Asparagus pubescens root on non-vascular smooth muscle in experimental animals","authors":"P. Nwafor, F. Okwuasaba, M. O. Uguru","doi":"10.4314/WAJPDR.V21I1.14756","DOIUrl":null,"url":null,"abstract":"The effect of methanolic extract of Asparagus pubescens root was investigated on non-vascular smooth muscle in experimental animals. The extract dose-dependently reduced spontaneous rhythmic contraction of rat uterine smooth muscle. It also inhibited acetylcholine, ergometrine, oxytocin, prostaglandin E2, 5-hydroxytryptamine as well as nicotine-induced contractions on rat uterine muscle. \nThese dose-related inhibitions were statistically significant (p Keywords : Asparagus pubescens , non-vascular smooth muscle, methanolic extract, non-specific mechanism West African Journal of Pharmacology and Drug Research Vol. 21 (1&2) 2005: pp. 31-36","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"13 1","pages":"31-36"},"PeriodicalIF":0.0000,"publicationDate":"2007-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"West African journal of pharmacology and drug research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/WAJPDR.V21I1.14756","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
The effect of methanolic extract of Asparagus pubescens root was investigated on non-vascular smooth muscle in experimental animals. The extract dose-dependently reduced spontaneous rhythmic contraction of rat uterine smooth muscle. It also inhibited acetylcholine, ergometrine, oxytocin, prostaglandin E2, 5-hydroxytryptamine as well as nicotine-induced contractions on rat uterine muscle.
These dose-related inhibitions were statistically significant (p Keywords : Asparagus pubescens , non-vascular smooth muscle, methanolic extract, non-specific mechanism West African Journal of Pharmacology and Drug Research Vol. 21 (1&2) 2005: pp. 31-36
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