Prognostic Value of p53 Expression in Intestinal Neoplasms - a Study in a Tertiary Health Care Centre

Abstract

Colorectal cancer is one of the most common tumours of the world with the varying distribution. Though small intestine is an uncommon site for tumour, it accounts for significant number of gastro-intestinal malignancies. Pathological assessment of the resected specimen is mandatory for assessing the postoperative outcome and the rationale for adjuvant therapy. Among the various prognostic factors, Mutation of the p53 tumour suppressor gene, plays an important role in the progression of colorectal carcinoma and so it represents a clinically useful marker of prognosis. The present study evaluates the role of p53 in intestinal neoplasms by assessing its level of expression and to correlate the level of p53 expression with the stage of the colorectal adenocarcinomas so that its prognostic value in colorectal adenocarcinomas can be calculated.