Live demonstration: A 128-channel spike sorting processor featuring 0.175 μW and 0.0033 mm2 per Channel in 65-nm CMOS

S. Zeinolabedin, A. Do, Dongsuk Jeon, D. Sylvester, T. T. Kim
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Abstract

Multi-electrode intracranial recording technology is highly required for various applications such as brain studies, brain machine interface (BMI) and treatment of disorders like epilepsy, memory loss and paralysis. The recording is done by inserting electrodes into the extracellular tissue of the brain to supposedly record the single-unit activity. However, the recorded signal is the summation of some near-by neurons activities and the background noise. Therefore, after recording and digitizing the signal by analog front-end, the first crucial step is to extract the information from extracellular recording [1]. This process is called spike sorting and shown in Fig. 1. It basically assigns the detected spike to their source neurons located near the corresponding recording electrodes.
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现场演示:一种128通道峰值排序处理器,每通道0.175 μW和0.0033 mm2,采用65纳米CMOS
多电极颅内记录技术在脑研究、脑机接口(BMI)以及癫痫、记忆丧失和瘫痪等疾病的治疗等各种应用中都有很高的需求。记录是通过将电极插入大脑的细胞外组织来记录单个单位的活动。然而,记录的信号是一些附近的神经元活动和背景噪声的总和。因此,在模拟前端对信号进行记录和数字化后,关键的第一步是从细胞外记录中提取信息[1]。这个过程被称为尖峰排序,如图1所示。它基本上将检测到的尖峰分配给位于相应记录电极附近的源神经元。
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