Alkaloid profiling in Galanthus gracilis Celak. from western Turkey by GC/MS

Ç. Karakoyun
{"title":"Alkaloid profiling in Galanthus gracilis Celak. from western Turkey by GC/MS","authors":"Ç. Karakoyun","doi":"10.26650/ISTANBULJPHARM.2018.422525","DOIUrl":null,"url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2018.422525 Galanthus L. is generally acknowledged as a valuable biological source due to its Amaryllidaceae alkaloids with unusual chemical structures and a wide variety of biological activities. Among these alkaloids, galanthamine is the first example of their practical application in medicine as a potent and selective inhibitor of the enzyme acetylcholinesterase, and already present on the market as a therapeutic agent for Alzheimer’s disease. Lycorine is the main Amaryllidaceae alkaloid deeply investigated for its biological activity for many years. In this study the alkaloidal profile of G. gracilis collected from western Aegean (Alankiyi/Bayindir) will be illustrated for the first time. GC-MS profiling was carried out on the crude alkaloidal extract obtained from dried and powdered plant material. 11 alkaloids were detected by GC-MS, including graciline, demethylhomolycorine and tazettine as the major ones.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"İstanbul Journal of Pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26650/ISTANBULJPHARM.2018.422525","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

DOI : 10.26650/IstanbulJPharm.2018.422525 Galanthus L. is generally acknowledged as a valuable biological source due to its Amaryllidaceae alkaloids with unusual chemical structures and a wide variety of biological activities. Among these alkaloids, galanthamine is the first example of their practical application in medicine as a potent and selective inhibitor of the enzyme acetylcholinesterase, and already present on the market as a therapeutic agent for Alzheimer’s disease. Lycorine is the main Amaryllidaceae alkaloid deeply investigated for its biological activity for many years. In this study the alkaloidal profile of G. gracilis collected from western Aegean (Alankiyi/Bayindir) will be illustrated for the first time. GC-MS profiling was carried out on the crude alkaloidal extract obtained from dried and powdered plant material. 11 alkaloids were detected by GC-MS, including graciline, demethylhomolycorine and tazettine as the major ones.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
葛兰的生物碱谱分析。通过气相色谱/质谱分析
由于其具有不同寻常的化学结构和多种生物活性的Amaryllidaceae生物碱,Galanthus L.被普遍认为是一种有价值的生物来源。在这些生物碱中,加兰他敏是它们作为乙酰胆碱酯酶的有效和选择性抑制剂在医学上实际应用的第一个例子,并且已经作为阿尔茨海默病的治疗剂出现在市场上。石蒜碱是菊科生物碱的主要成分,其生物活性已被研究多年。本研究首次对在爱琴海西部地区(Alankiyi/Bayindir)采集的凤尾草生物碱谱进行了分析。采用气相色谱-质谱法对干燥和粉末状植物原料的生物碱粗提物进行了分析。GC-MS共检测到11种生物碱,其中以格西林、去甲基高氯碱和他泽汀为主要成分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Ameliorative effect of cranberry on erectile function in diabetic rats Inhibitory potentials of Moringa oleifera on activities of neuraminidase, xanthine oxidase and adenosine deaminase A chemometrics-based approach for the determination of thymoquinone from Nigella sativa L. (Black Cumin) seeds of different geographical regions using the HPLC technique Virtual drug screening for p65/rela subunit of nf-κb: Promising repurposable drugs in the treatment of stress-based diseases Taxonomic significance of anatomy and achene micromorphology of selected Cousinia Cass. species (Asteraceae)
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1