Alkaloid profiling in Galanthus gracilis Celak. from western Turkey by GC/MS

Ç. Karakoyun
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Abstract

DOI : 10.26650/IstanbulJPharm.2018.422525 Galanthus L. is generally acknowledged as a valuable biological source due to its Amaryllidaceae alkaloids with unusual chemical structures and a wide variety of biological activities. Among these alkaloids, galanthamine is the first example of their practical application in medicine as a potent and selective inhibitor of the enzyme acetylcholinesterase, and already present on the market as a therapeutic agent for Alzheimer’s disease. Lycorine is the main Amaryllidaceae alkaloid deeply investigated for its biological activity for many years. In this study the alkaloidal profile of G. gracilis collected from western Aegean (Alankiyi/Bayindir) will be illustrated for the first time. GC-MS profiling was carried out on the crude alkaloidal extract obtained from dried and powdered plant material. 11 alkaloids were detected by GC-MS, including graciline, demethylhomolycorine and tazettine as the major ones.
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葛兰的生物碱谱分析。通过气相色谱/质谱分析
由于其具有不同寻常的化学结构和多种生物活性的Amaryllidaceae生物碱,Galanthus L.被普遍认为是一种有价值的生物来源。在这些生物碱中,加兰他敏是它们作为乙酰胆碱酯酶的有效和选择性抑制剂在医学上实际应用的第一个例子,并且已经作为阿尔茨海默病的治疗剂出现在市场上。石蒜碱是菊科生物碱的主要成分,其生物活性已被研究多年。本研究首次对在爱琴海西部地区(Alankiyi/Bayindir)采集的凤尾草生物碱谱进行了分析。采用气相色谱-质谱法对干燥和粉末状植物原料的生物碱粗提物进行了分析。GC-MS共检测到11种生物碱,其中以格西林、去甲基高氯碱和他泽汀为主要成分。
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