QTc interval prolongation and cirrhosis severity in non-alcoholic patients

A. Saeidinia, A. Salari, A. Shafaghi, M. Ofoghi
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Abstract

Introduction: Chronic liver disease is a major health problem and important causes of mortality and morbidity. Cirrhosis is associated with cardiovascular abnormalities. QT interval prolongation is one of the electrophysiological indicators of cirrhotic cardiomyopathy. So in this study we evaluated the QTc interval prolongation and cirrhosis severity in non-alcoholic patients admitted in Razi hospital in Rasht during 2011-2012. Material & methods: This survey was conducted as a cross-sectional descriptive study. A 12-lead surface ECG and echocardiographic study was obtained from all subjects. A 12-lead electrocardiogram recorded at 50 mm/second to measure the QT interval. The mean QT interval in every 12 leads was documented for each patient. The QT corrected for RR (QTc) was calculated. The quantitative and qualitative data were analyzed by Chi-square, ANOVA, Linear regression test and Fisher’s exact tests. Results: The mean of age was 52.78±15.2. Sixty-three persons were male, and others were female. The most common cause of cirrhosis in our study population was Hepatitis C virus. Prolonged QTc interval was seen in 48% of subjects. There was no significant correlation between age and mean of laboratory data and QTc prolongation (P>0.05). There was no significant correlation between causes of cirrhosis and QTc prolongation (P>0.05). There was significant correlation between severity of cirrhosis and QTc (P=0.020). Conclusion: Majority of patients with cirrhosis showed QTc interval prolongation, which related significantly with worsening the severity of the disease, regardless of the etiology of cirrhosis.
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非酒精患者QTc间期延长与肝硬化严重程度的关系
慢性肝病是主要的健康问题,也是导致死亡和发病的重要原因。肝硬化与心血管异常有关。QT间期延长是肝硬化心肌病的电生理指标之一。因此,本研究对2011-2012年在拉希特市拉兹医院住院的非酒精患者的QTc间期延长和肝硬化严重程度进行了评估。材料与方法:本调查采用横断面描述性研究。对所有受试者进行12导联体表心电图和超声心动图检查。以50毫米/秒的速度记录12导联心电图,测量QT间期。记录每位患者每12导联的平均QT间期。计算经RR校正的QT (QTc)。定量和定性资料采用卡方检验、方差分析、线性回归检验和Fisher精确检验。结果:患者平均年龄为52.78±15.2岁。其中63人为男性,其余为女性。在我们的研究人群中,肝硬化最常见的原因是丙型肝炎病毒。48%的受试者QTc间期延长。年龄、实验室数据平均值与QTc延长无显著相关(P < 0.05)。肝硬化原因与QTc延长无显著相关性(P < 0.05)。肝硬化严重程度与QTc有显著相关性(P=0.020)。结论:绝大多数肝硬化患者QTc间期延长,且与肝硬化的病因无关,QTc间期延长与病情加重有显著关系。
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