Shiva Naga Vara Prasad Bathula, Vijayshekar Dustakar
{"title":"Alzheimer’s disease: Recent advances in diagnosis and overview of clinical research in newer treatments","authors":"Shiva Naga Vara Prasad Bathula, Vijayshekar Dustakar","doi":"10.3109/10601333.2011.560154","DOIUrl":null,"url":null,"abstract":"Alzheimer’s disease (AD) is a progressive and fatal neurodegenerative disorder manifested by cognitive and memory deterioration, progressive impairment of activities of daily living, and a variety of neuropsychiatric symptoms and behavioral disturbances. This article discusses worldwide prevalence patterns, history, and summarizes hypotheses about the causes of AD. Currently available diagnostic methods, their effectiveness of, and problems with, different methods and recent advances are thoroughly discussed. Finally, current treatment strategies are discussed in light of the benefits and drawbacks of different therapeutic approaches along with ongoing drugs under development.","PeriodicalId":10446,"journal":{"name":"Clinical Research and Regulatory Affairs","volume":"20 1","pages":"34 - 37"},"PeriodicalIF":0.0000,"publicationDate":"2011-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Research and Regulatory Affairs","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/10601333.2011.560154","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Alzheimer’s disease (AD) is a progressive and fatal neurodegenerative disorder manifested by cognitive and memory deterioration, progressive impairment of activities of daily living, and a variety of neuropsychiatric symptoms and behavioral disturbances. This article discusses worldwide prevalence patterns, history, and summarizes hypotheses about the causes of AD. Currently available diagnostic methods, their effectiveness of, and problems with, different methods and recent advances are thoroughly discussed. Finally, current treatment strategies are discussed in light of the benefits and drawbacks of different therapeutic approaches along with ongoing drugs under development.
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