The Effects of Vitamin B6 on the Liver of Diabetic Rats: A Morphological and Biochemical Study

Ş. Bolkent, O. Sacan, A. Karatuğ, R. Yanardag
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引用次数: 12

Abstract

The aim of present study was to investigate the morphological and biochemical effects of vitamin B6 on liver tissue of normal and streptozotocin-diabetic rats. Experimental diabetes was induced by intraperitonal injection of streptozotocin (STZ) in a single dose of 65 mg/kg. Vitamin B6 was administered by subcutaneous injection at a dose of 20 mg/kg for 15 days. The degenerative changes in the liver tissue, biochemical changes in blood glucose levels and in serum aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) activities were determined. Degenerative changes observed in the diabetic animals by light microscopic investigations. Blood glucose levels, serum AST, ALT and ALP activities increased in the diabetic group. On the other hand, the treatment with vitamin B6 for 15 days reversed these effects. As a result, all of the obtained morphological and biochemical findings led to the conclusion that vitamin B6 has a protective effect against diabetes mellitus.
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维生素B6对糖尿病大鼠肝脏的形态学和生化影响
本研究旨在探讨维生素B6对正常大鼠和链脲霉素糖尿病大鼠肝组织形态和生化的影响。采用单次腹腔注射链脲佐菌素(STZ) 65 mg/kg诱导实验性糖尿病。维生素B6以20 mg/kg的剂量皮下注射,连续15天。测定肝组织退行性改变、血糖生化变化及血清天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)和碱性磷酸酶(ALP)活性。光镜下观察糖尿病动物的退行性改变。糖尿病组血糖水平升高,血清AST、ALT、ALP活性升高。另一方面,用维生素B6治疗15天逆转了这些效果。所有形态学和生化实验结果均表明维生素B6对糖尿病具有保护作用。
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