Bone turnover markers reference database at University Medical Center, Ho Chi Minh city

The South Dakota journal of medicine and pharmacy Pub Date : 2023-04-01 DOI:10.34071/jmp.2023.2.13

Thanh Cao Ngoc, Thuy Tran Hong

{"title":"Bone turnover markers reference database at University Medical Center, Ho Chi Minh city","authors":"Thanh Cao Ngoc, Thuy Tran Hong","doi":"10.34071/jmp.2023.2.13","DOIUrl":null,"url":null,"abstract":"Objectives: To establish reference ranges for serum bone turnover markers including Osteocalcin (OC), Procollagen type 1 amino-terminal propeptide (P1NP), and Beta-CrossLaps (beta-CTX) in premenopausal women at University Medical Center, Ho Chi Minh City.\n\nMethods: A cross-sectional study was conducted on 157 women aged 20 to 44 years at University Medical Center, Ho Chi Minh City from December 2022 to February 2023. Demographic information, biochemical markers, and serum levels of OC, P1NP, and beta-CTX were recorded.\n\nResults: The mean serum levels of OC, P1NP, and beta-CTX were 15.57 ± 4.75 ng/mL, 41.98 ± 16.62 μg/L, and 314.03 ± 150.42 pg/mL, respectively. The levels of bone turnover markers varied significantly among different age groups (p < 0.01). Serum levels of OC, P1NP, and beta-CTX were negatively correlated with age, with r values of -0.44, -0.35 and -0.43 respectively (p < 0.01).\n\nConclusion: The reference ranges for serum markers of bone turnover including OC, P1NP, and beta-CTX were 15.57 ± 4.75 ng/mL, 41.98 ± 16.62 μg/L, and 314.03 ± 150.42 pg/mL, respectively, in premenopausal women aged 20 to 44 years. Serum levels of OC, P1NP, and beta-CTX were negatively correlated with age in a moderate degree\n\nKey words: osteocalcin, P1NP, beta-CTX, bone turnover markers, premenopausal women.","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"2 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The South Dakota journal of medicine and pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34071/jmp.2023.2.13","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: To establish reference ranges for serum bone turnover markers including Osteocalcin (OC), Procollagen type 1 amino-terminal propeptide (P1NP), and Beta-CrossLaps (beta-CTX) in premenopausal women at University Medical Center, Ho Chi Minh City. Methods: A cross-sectional study was conducted on 157 women aged 20 to 44 years at University Medical Center, Ho Chi Minh City from December 2022 to February 2023. Demographic information, biochemical markers, and serum levels of OC, P1NP, and beta-CTX were recorded. Results: The mean serum levels of OC, P1NP, and beta-CTX were 15.57 ± 4.75 ng/mL, 41.98 ± 16.62 μg/L, and 314.03 ± 150.42 pg/mL, respectively. The levels of bone turnover markers varied significantly among different age groups (p < 0.01). Serum levels of OC, P1NP, and beta-CTX were negatively correlated with age, with r values of -0.44, -0.35 and -0.43 respectively (p < 0.01). Conclusion: The reference ranges for serum markers of bone turnover including OC, P1NP, and beta-CTX were 15.57 ± 4.75 ng/mL, 41.98 ± 16.62 μg/L, and 314.03 ± 150.42 pg/mL, respectively, in premenopausal women aged 20 to 44 years. Serum levels of OC, P1NP, and beta-CTX were negatively correlated with age in a moderate degree Key words: osteocalcin, P1NP, beta-CTX, bone turnover markers, premenopausal women.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

胡志明市大学医学中心骨转换标志物参考数据库

目的:建立胡志明市大学医学中心绝经前妇女血清骨转换标志物骨钙素(OC)、前胶原1型氨基末端前肽(P1NP)和β -交叉肽(β - ctx)的参考范围。方法:对2022年12月至2023年2月在胡志明市大学医学中心就诊的157名年龄在20 ~ 44岁的女性进行横断面研究。记录人口统计学信息、生化指标及血清OC、P1NP、β - ctx水平。结果:大鼠血清OC、P1NP、β - ctx平均水平分别为15.57±4.75 ng/mL、41.98±16.62 μg/L、314.03±150.42 pg/mL。不同年龄组骨转换标志物水平差异有统计学意义(p < 0.01)。血清OC、P1NP、β - ctx水平与年龄呈负相关，r值分别为-0.44、-0.35、-0.43 (p < 0.01)。结论:20 ~ 44岁绝经前妇女血清骨转换标志物OC、P1NP、β - ctx参考范围分别为15.57±4.75 ng/mL、41.98±16.62 μg/L、314.03±150.42 pg/mL。血清OC、P1NP、β - ctx水平与年龄呈中等程度负相关。关键词:骨钙素、P1NP、β - ctx、骨转换标志物、绝经前妇女。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

The South Dakota journal of medicine and pharmacy

自引率

0.00%

发文量