Antibiotic Resistance and its Association with Biocides Susceptibilities among Microbial Isolates in an Egyptian Hospital

S. A. Daniel, M. Shawky, H. Abou-Shleib, M. El-Nakeeb
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引用次数: 5

Abstract

Background: Recently there has been a growing concern that the indiscriminate use of antimicrobial agents in the household, food industry and in hospitals may contribute to the emergence of bacteria resistant to antibiotics. Aim of the work: To detect any possible link between the susceptibility profiles of different clinical and environmental isolates to biocides and antibiotics in an Egyptian hospital. Methods: 66 different microbial isolates were isolated from different clinical specimens and different environmental samples obtained from a University Hospital in Alexandria. These isolates were screened for their susceptibility to 22 broad spectrum antibiotics using disc agar diffusion technique. Also the susceptibility of the isolates to 6 commonly used biocides was screened through MIC determination by agar dilution technique. Correlations between the obtained data were made through Spearman’s correlation using SPSS ® Statistical program. Results: 62% of the isolates were multidrug resistant (MDR); and 11% were extremely drug resistant (XDR). On the other hand, 34% of the tested isolates were multi-disinfectant reduced susceptibility (MDRS) isolates. The statistical analysis of the obtained data revealed a moderate positive correlation between antibiotic resistance and biocide tolerance (0.376≥ρ≥0.278, p<0.05). In addition, strong significant correlations (p<0.01) were also found between reduced susceptibilities to multiple biocides such as benzalkonium chloride (BK), cetrimide (CET), chlorhexidine (CHX), povidone-iodine (PVPI) and Dettol ® . Conclusion: Cross-resistance between biocides and antibiotics can aggravate the existing problem of antibiotic resistance in hospitals.
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埃及一家医院微生物分离株抗生素耐药性及其与杀菌剂敏感性的关系
背景:最近,人们越来越担心,在家庭、食品工业和医院中不加选择地使用抗菌剂可能会导致耐抗生素细菌的出现。工作目的:检测埃及一家医院中不同临床和环境分离株对杀菌剂和抗生素的敏感性之间的任何可能联系。方法:从亚历山大市某大学医院不同临床标本和不同环境标本中分离出66株不同的微生物。采用圆盘琼脂扩散技术对22种广谱抗生素进行敏感性筛选。用琼脂稀释法进行MIC测定,筛选菌株对6种常用杀菌剂的敏感性。使用SPSS®统计程序对所得数据进行Spearman相关分析。结果:62%的分离株具有多重耐药(MDR);11%为极度耐药(XDR)。另一方面,34%的检测分离株为多重消毒液降低敏感性(MDRS)分离株。对所得数据进行统计分析,抗生素耐药性与杀菌剂耐受性呈中度正相关(0.376≥ρ≥0.278,p<0.05)。此外,对苯扎氯铵(BK)、西曲胺(CET)、氯己定(CHX)、聚维酮碘(PVPI)和Dettol®等多种杀菌剂的敏感性也显著降低(p<0.01)。结论:杀菌剂与抗生素交叉耐药会加重医院现有的抗生素耐药问题。
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