A Smart and Potential approach for Transdermal Drug Delivery using Microneedles: A Review

Abstract

Transdermal drug delivery system used to transport the drug across the skin deep into systemic circulation. The main advantages of Transdermal drug delivery system improved patient compliance, sustained release, avoidance of gastric irritation, as well as elimination of pre-systemic first-pass effect. But most of therapeutic agents is limited due to thickness of stratum corneum, which act as a barrier for the delivery of various drug molecules and only few molecules are able to reach the action site. Microneedles are the new form of delivery system, which are used to increase the delivery of drug through this route and overcoming the number of problems related to conventional drug delivery system the main aim of this review to focus on new innovation in transdermal drug delivery systems. In the microneedle drug delivery system, the skin is temporarily broken, that creating micron size pathways that deliver the sufficient amount of drug directly into the stratum corneum from which the drug can directly go into the systemic circulation. In this review, we describe different type of microneedles can be solid, coated, dissolving and biodegradable microneedles and their method of fabrication. Microneedles can be manufactured in different forms like hollow, solid, and dissolving. Also describe materials used for fabrication, fabrication techniques, methodology of drug delivery such as Poke and patch, Coat and poke, Poke and release, Poke and flow and evaluation parameters.