Phenylcarbamic acid derivatives with integrated n-phenylpiperazine moiety in the structure – kinetics of alkaline hydrolysis study / Deriváty kyseliny fenylkarbámovej s integrovanou n-fenylpiperazínovou zložkou v štruktúre – štúdium kinetiky alkalickej hydrolýzy

Acta Facultatis Pharmaceuticae Universitatis Comenianae Pub Date : 2015-12-01 DOI:10.1515/AFPUC-2015-0032

M. Stankovicová, V. Miháliková, Ľ. Mezovský, A. Lašáková, V. Medlenová, I. Malík

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Abstract

Slovak abstract Acta Fac. Pharm. Univ. Comen. LXII, 2015 (2): 38-42. ISSN 1338-6786 (online) and ISSN 0301-2298 (print version), DOI: 10.1515/afpuc-2015-0032 Received September 22, 2015, accepted October 28, 2015 Original research article/Review * E-mail: stankovicm@fpharm.uniba.sk Deriváty kyseliny fenylkarbámovej – alkalická hydrolýza – chemická kinetika – antiarytmiká – stabilita Kľúčové slová: Univerzita Komenského v Bratislave, Farmaceutická Fakulta, Katedra Farmaceutickej Chémie, Bratislava, Slovenská republika Comenius University in Bratislava, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Bratislava, Slovak Republic / Phenylcarbamic acid derivatives with integrated n-phenylpiperazine moiety in the... Stankovičová M. et al. Acta Fac. Pharm. Univ. Comen. LXII, 2015 (2): 38-42. 40 39 parameters, i.e. activation energy EA determined from temperature dependence of the rate constants. Following the evaluation of complex physicochemical properties of basic esters, the aim of this work is the study of kinetics of their alkaline hydrolysis. In terms of fundamental structural aspects, the influence of alkoxy side chain attached to phenyl ring as well as the substitution on N-phenylpiperazin-1-yl moiety within the structure on the stability is evaluated. MATERIALS AND METHODS

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