Synthesis, Characterization and Antimicrobial Evaluation of Ru(II) and Co(III) Complexes of Phenylene-1,2-bis(iminoflavone) Derivatives

Abstract

Bioactive ruthenium and cobalt scaffolds of molecular formula [Ru(PPh3)2L] and [Co(H2O)Cl L] {where L represents the tetradentate ligands (E)-4-((2-((E)-(3-hydroxy-2-(4-substitutedphenyl)-4a,8a-dihydro-4Hchromen-4-ylidene)amino)phenyl)imino)-2-(4-substituted phenyl)-4H-chromen-3-ol (phenylenebis(iminoflavone)} have been synthesized from Ru(II) precursor [Ru(PPh3)4Cl2] and CoCl2.3H2O and phenylenebis(iminoflavone). Tetradentate ligands of flavone (phenylenebis(iminoflavone)) have been derived by the condensation of 3-hydroxy-2(4-substitutedphenyl)-4H-chromen-4-one with o-phenylenediamine. These ligands and scaffolds were characterized by elemental analysis, NMR, IR, ESI-MS, UV-Visible spectrometry, and conductometric measurement. These ligands and scaffolds were screened the in vitro toxicity for antimicrobial activity against the growth of bacterial species Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi and fungal species Candida albicans and Aspergillus flavus.