Mechanisms in Emotional Information Processing in Individuals with Major Depressive Disorder: An Event-Related Potential Study of an Information Processing Model.

IF 0.5 4区 医学 Q4 PHARMACOLOGY & PHARMACY Psychiatry and Clinical Psychopharmacology Pub Date : 2023-06-01 DOI:10.5152/pcp.2023.22471
Daniel Kwasi Ahorsu, Ken Ho Ming Chung, Ho Hon Wong, Michael Gar Chung Yiu, Yat Fung Mok, Ka Shun Lei, Hector Wing Hong Tsang
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Abstract

Background: Individuals with major depressive disorder have a cognitive bias toward emotional stimuli, which influences the quality and speed of emotional information processing. This study aimed to understand the factors underlying this bias by identifying when it occurs during information processing using an information processing model.

Methods: A total of 57 participants-19 each [ (16 (84.21%) females and 3 (15.79%) males per group)], for the first-episode MDD (FMDD), recurrent episodes MDD (RMDD), and healthy controls (HCs) - matched for sex and hand preference, completed event-related potentials (ERP) to perform psychological function and a choice response time task.

Results: Results revealed that recurrent episodes major depressive disorder participants had decreased N2b and P3b amplitudes but increased contingent negative variation during the processing of happy and neutral facial stimuli, relative to their counterparts. Both recurrent episodes major depressive disorder and first-episode major depressive disorder participants used a parallel information processing strategy for happy information at P3a latency, while healthy controls used a linear information processing strategy.

Conclusion: The use of a parallel processing strategy among individuals with major depressive disorder may have led to impaired "happy" information processes, possibly explaining why individuals with major depressive disorder are less efficient than healthy controls. The results suggest the possibility that biases related to the processing of "happy" information among individuals with major depressive disorder may be related to a tendency for these individuals to engage in superficial decision-making. Future research is needed to examine the processes contributing to people with major depressive disorder having challenges with inhibition-facilitation of emotional stimuli.

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重度抑郁症患者的情绪信息处理机制:信息处理模型的事件相关电位研究。
背景:重度抑郁症患者会对情绪刺激产生认知偏差,从而影响情绪信息处理的质量和速度。本研究旨在通过使用信息加工模型识别信息加工过程中何时会出现这种偏差,从而了解导致这种偏差的因素:共57名参与者,每组19名[(每组16名女性(84.21%)和3名男性(15.79%)]],分别为首次发作多发性抑郁症(FMDD)、复发性多发性抑郁症(RMDD)和健康对照组(HCs)--性别和手的偏好相匹配,完成事件相关电位(ERP)以执行心理功能和选择反应时间任务:结果发现,复发性重度抑郁症患者在处理快乐和中性面部刺激时,N2b和P3b振幅下降,但或然负变异增加。复发性重度抑郁障碍和首发重度抑郁障碍患者在P3a潜伏期对快乐信息采用平行信息处理策略,而健康对照组采用线性信息处理策略:结论:重度抑郁障碍患者使用并行处理策略可能导致 "快乐 "信息处理受损,这可能解释了为什么重度抑郁障碍患者的效率低于健康对照组。研究结果表明,重度抑郁障碍患者在处理 "快乐 "信息时出现的偏差,可能与他们倾向于肤浅决策有关。未来的研究还需要对导致重度抑郁障碍患者在抑制-促进情绪刺激方面遇到困难的过程进行研究。
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来源期刊
Psychiatry and Clinical Psychopharmacology
Psychiatry and Clinical Psychopharmacology Medicine-Psychiatry and Mental Health
CiteScore
1.00
自引率
14.30%
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0
期刊介绍: Psychiatry and Clinical Psychopharmacology aims to reach a national and international audience and will accept submissions from authors worldwide. It gives high priority to original studies of interest to clinicians and scientists in applied and basic neurosciences and related disciplines. Psychiatry and Clinical Psychopharmacology publishes high quality research targeted to specialists, residents and scientists in psychiatry, psychology, neurology, pharmacology, molecular biology, genetics, physiology, neurochemistry, and related sciences.
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