Caro's Acid-Silica Gel Catalyzed Regioselective Ring Opening of Epoxides with Indoles and Imidazoles under Solvent-Free Conditions

Abstract

An efficient and facile procedure has been developed for the ring opening of epoxides with nitrogen heterocycles such as indole and imidazole in the presence of Caro's acid-silica gel (CA-SiO2) as catalyst in solventless system. The reactions were administered underneath Solvent-free conditions. The current methodology offers many benefits like good yields, easy procedure, simple work-up and ecofriendly reaction condition. The catalyst is well ready, stable and economical underneath the reaction conditions.