Immunological considerations and vaccines against COVID-19

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引用次数: 1

Abstract

The outbreak COVID-19 is considered as a revolution in history of biological science. SARS-CoV-2 is a main cause of COVID-19 having resemblance with MERS-CoV and SARS-CoV. The response of host to the infection of SARS-CoV is multiform and strong. Initially, an effective host defense in the lung is affiliated with disease resolution and mild symptoms. The escaping of virus from immune response can lead to damage the alveoli, systematic inflammation, and ineffective lung repair mechanism with associated organ dysfunction. The immunological responses are necessary to fight with the virus and an effective and a safe vaccine is needed to overcome the pandemic. The development of vaccine is progressing fast, billions of dollars committed with more than 200 candidates before even knowing whether a vaccine candidate will succeed.
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针对COVID-19的免疫学考虑和疫苗
新冠肺炎疫情被认为是生命科学史上的一次革命。SARS-CoV-2与MERS-CoV和SARS-CoV有相似之处,是COVID-19的主要病因。宿主对SARS-CoV感染的反应是多种多样且强烈的。最初,肺部有效的宿主防御与疾病消退和轻微症状有关。病毒从免疫应答中逃逸可导致肺泡损伤、全身炎症和肺修复机制失效并伴有器官功能障碍。免疫反应是抗击病毒所必需的,需要一种有效和安全的疫苗来克服这一流行病。疫苗的开发进展迅速,甚至在知道一种候选疫苗是否成功之前,就已经投入了数十亿美元用于200多种候选疫苗。
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