Secoisolariciresinol diglucoside from flaxseed delays the development of type 2 diabetes in Zucker rat.

K. Prasad
{"title":"Secoisolariciresinol diglucoside from flaxseed delays the development of type 2 diabetes in Zucker rat.","authors":"K. Prasad","doi":"10.1067/MLC.2001.115717","DOIUrl":null,"url":null,"abstract":"Previous research has suggested that type 1 diabetes mellitus may be due to oxidative stress. The role of oxidative stress in type 2 diabetes is not known. Secoisolariciresinol diglucoside (SDG) antioxidant, obtained from flaxseed, has been reported to prevent type 1 diabetes in a rat model. However, its effectiveness in type 2 diabetes is not known. An investigation was made of the effects of SDG isolated from flaxseed (40 mg/kg body wt, orally in drinking water) on the development of diabetes in Zucker diabetic fatty (ZDF)/Gmi-fa/fa female rats, a model of human type 2 diabetes, to determine whether this type of diabetes is due to oxidative stress and whether SDG could prevent the development of diabetes. A total of 10 Zucker lean control and 26 ZDF rats were used in this study. Incidence of diabetes was 100% in untreated and 20% in SDG-treated ZDF rats by the age of 72 days (P <.01). The rats that did not develop diabetes by 72 days of age in the SDG-treated group developed diabetes later on (age 72 to 99 days) except for 10% of the rats that did not develop diabetes for the duration of the study (101 days of age), suggesting that SDG retarded the development of diabetes. Diabetes was associated with an increase in oxidative stress as suggested by an increase in serum malondialdehyde (P <.01). Also, diabetes was associated with an increase in serum total cholesterol and triglycerides (P <.05) and glycated hemoglobin A(1C) (P <.05). ZDF rats treated with SDG that did not develop diabetes by 70 days of age had no increase in oxidative stress, serum total cholesterol, and glycated hemoglobin. These results suggest that type 2 diabetes is associated with an increase in oxidative stress and that SDG is effective in retarding the development of diabetes.","PeriodicalId":23085,"journal":{"name":"The Journal of laboratory and clinical medicine","volume":"37 1","pages":"32-9"},"PeriodicalIF":0.0000,"publicationDate":"2001-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"175","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of laboratory and clinical medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1067/MLC.2001.115717","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 175

Abstract

Previous research has suggested that type 1 diabetes mellitus may be due to oxidative stress. The role of oxidative stress in type 2 diabetes is not known. Secoisolariciresinol diglucoside (SDG) antioxidant, obtained from flaxseed, has been reported to prevent type 1 diabetes in a rat model. However, its effectiveness in type 2 diabetes is not known. An investigation was made of the effects of SDG isolated from flaxseed (40 mg/kg body wt, orally in drinking water) on the development of diabetes in Zucker diabetic fatty (ZDF)/Gmi-fa/fa female rats, a model of human type 2 diabetes, to determine whether this type of diabetes is due to oxidative stress and whether SDG could prevent the development of diabetes. A total of 10 Zucker lean control and 26 ZDF rats were used in this study. Incidence of diabetes was 100% in untreated and 20% in SDG-treated ZDF rats by the age of 72 days (P <.01). The rats that did not develop diabetes by 72 days of age in the SDG-treated group developed diabetes later on (age 72 to 99 days) except for 10% of the rats that did not develop diabetes for the duration of the study (101 days of age), suggesting that SDG retarded the development of diabetes. Diabetes was associated with an increase in oxidative stress as suggested by an increase in serum malondialdehyde (P <.01). Also, diabetes was associated with an increase in serum total cholesterol and triglycerides (P <.05) and glycated hemoglobin A(1C) (P <.05). ZDF rats treated with SDG that did not develop diabetes by 70 days of age had no increase in oxidative stress, serum total cholesterol, and glycated hemoglobin. These results suggest that type 2 diabetes is associated with an increase in oxidative stress and that SDG is effective in retarding the development of diabetes.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
从亚麻籽中提取的二糖苷可延缓Zucker大鼠2型糖尿病的发展。
先前的研究表明,1型糖尿病可能是由氧化应激引起的。氧化应激在2型糖尿病中的作用尚不清楚。从亚麻籽中提取的二糖苷(SDG)抗氧化剂已被报道在大鼠模型中预防1型糖尿病。然而,它对2型糖尿病的疗效尚不清楚。研究了亚麻籽分离物SDG (40 mg/kg体重量,饮用水中口服)对人类2型糖尿病模型Zucker糖尿病脂肪(ZDF)/Gmi-fa/fa雌性大鼠糖尿病发展的影响,以确定该型糖尿病是否由氧化应激引起,以及SDG是否能预防糖尿病的发展。采用Zucker lean对照10只,ZDF大鼠26只。72日龄时,未治疗组糖尿病发生率为100%,sdg组为20% (P < 0.01)。除研究期间(101日龄)未患糖尿病的大鼠中有10%的大鼠在研究期间(72至99日龄)未患糖尿病外,在72日龄时未患糖尿病的大鼠出现了糖尿病,这表明SDG延缓了糖尿病的发展。血清丙二醛升高提示糖尿病与氧化应激升高相关(P < 0.01)。此外,糖尿病与血清总胆固醇和甘油三酯(P < 0.05)和糖化血红蛋白A(P < 0.05)升高有关。经SDG治疗的ZDF大鼠在70日龄前未发生糖尿病,氧化应激、血清总胆固醇和糖化血红蛋白均未增加。这些结果表明,2型糖尿病与氧化应激增加有关,而SDG在延缓糖尿病的发展方面是有效的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Prometheus. Foie gras. Gene expression in giant-cell tumors. The lighthouse at Coxsackie, New York. Mechanisms of platelet retention in the collagen-coated-bead column.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1