De rechten, inclusief en met name de rechten voor uitvoering, liggen voor alle teksten bij de auteur en het is dan ook verplicht om voor elke vorm van uitvoering toestemming bij de betreffende schrijver aan te vragen. Voor elke schrijver is het van groot belang om te weten of zijn teksten worden uitgevoerd, dus neem alstublieft bij elke lezing, enscenering, bespreking in het onderwijs e.d. even contact op met de auteur! Het contact adres voor deze tekst is:
{"title":"Prometheus.","authors":"Ko van den Bosch, Ko van den Bosch","doi":"10.2307/j.ctv18zhddx.7","DOIUrl":"https://doi.org/10.2307/j.ctv18zhddx.7","url":null,"abstract":"De rechten, inclusief en met name de rechten voor uitvoering, liggen voor alle teksten bij de auteur en het is dan ook verplicht om voor elke vorm van uitvoering toestemming bij de betreffende schrijver aan te vragen. Voor elke schrijver is het van groot belang om te weten of zijn teksten worden uitgevoerd, dus neem alstublieft bij elke lezing, enscenering, bespreking in het onderwijs e.d. even contact op met de auteur! Het contact adres voor deze tekst is:","PeriodicalId":23085,"journal":{"name":"The Journal of laboratory and clinical medicine","volume":"49 2 1","pages":"498"},"PeriodicalIF":0.0,"publicationDate":"2021-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77324332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Foie gras.","authors":"Claus A Pierach","doi":"10.1201/b13702-9","DOIUrl":"https://doi.org/10.1201/b13702-9","url":null,"abstract":"","PeriodicalId":23085,"journal":{"name":"The Journal of laboratory and clinical medicine","volume":"159 1","pages":"231-2"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80040501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-07-15DOI: 10.1200/JCO.2004.22.14_SUPPL.9050
K. Skubitz, E. Cheng, D. Clohisy, R. Thompson, A. Skubitz
Malignant transformation is thought to be associated with changes in the expression of a number of genes, and this alteration in gene expression is considered critical to the development of the malignant phenotype. In this study, gene expression in 8 samples of giant-cell tumor (GCT) of bone, as well as in bone at the site of osteoarthritis and in a variety of normal tissues, was determined at Gene Logic Inc (Gaithersburg, Md) with the use of Affymetrix GeneChip U_133 arrays containing approximately 40,000 genes/expressed sequence tags (ESTs). Gene-expression analysis was performed with the use of the Gene Logic GeneExpress Software System. Differences in gene expression between GCTs and bone were observed. In addition, genes expressed uniquely in GCTs among these and 519 samples from 20 other tissue types were identified. Some of the genes that were found to be overexpressed in GCTs, such as tartrate-resistant acid phosphatase and the lysosomal H + -transporting ATPase, are also expressed by osteoclasts. Osteoprotegrin ligand (OPGL) was also selectively overexpressed in GCTs. The genes found to be overexpressed in GCTs appear to reflect the genetic profile of osteoclast-lineage cells and also the genetic profile of an osteoclastogenic environment. The genes identified in this study may play a role in the pathogenesis of GCTs, confirm the likely importance of OPGL in GCT pathogenesis, and may indicate other possible targets to which antitumor therapy could be directed.
{"title":"Gene expression in giant-cell tumors.","authors":"K. Skubitz, E. Cheng, D. Clohisy, R. Thompson, A. Skubitz","doi":"10.1200/JCO.2004.22.14_SUPPL.9050","DOIUrl":"https://doi.org/10.1200/JCO.2004.22.14_SUPPL.9050","url":null,"abstract":"Malignant transformation is thought to be associated with changes in the expression of a number of genes, and this alteration in gene expression is considered critical to the development of the malignant phenotype. In this study, gene expression in 8 samples of giant-cell tumor (GCT) of bone, as well as in bone at the site of osteoarthritis and in a variety of normal tissues, was determined at Gene Logic Inc (Gaithersburg, Md) with the use of Affymetrix GeneChip U_133 arrays containing approximately 40,000 genes/expressed sequence tags (ESTs). Gene-expression analysis was performed with the use of the Gene Logic GeneExpress Software System. Differences in gene expression between GCTs and bone were observed. In addition, genes expressed uniquely in GCTs among these and 519 samples from 20 other tissue types were identified. Some of the genes that were found to be overexpressed in GCTs, such as tartrate-resistant acid phosphatase and the lysosomal H + -transporting ATPase, are also expressed by osteoclasts. Osteoprotegrin ligand (OPGL) was also selectively overexpressed in GCTs. The genes found to be overexpressed in GCTs appear to reflect the genetic profile of osteoclast-lineage cells and also the genetic profile of an osteoclastogenic environment. The genes identified in this study may play a role in the pathogenesis of GCTs, confirm the likely importance of OPGL in GCT pathogenesis, and may indicate other possible targets to which antitumor therapy could be directed.","PeriodicalId":23085,"journal":{"name":"The Journal of laboratory and clinical medicine","volume":"13 1","pages":"193-200"},"PeriodicalIF":0.0,"publicationDate":"2004-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88367471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The lighthouse at Coxsackie, New York.","authors":"Dale E Hammerschmidt","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23085,"journal":{"name":"The Journal of laboratory and clinical medicine","volume":"142 3","pages":"205"},"PeriodicalIF":0.0,"publicationDate":"2003-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24038005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-07-01DOI: 10.1111/J.1538-7836.2003.TB05661.X
M. Kaneko, O. Cuyun-Lira, T. Takafuta, K. Suzuki-Inoue, K. Satoh, K. Ohtsuki, M. Ohnishi, M. Arai, Y. Yatomi, Y. Ozaki
Although the glass-bead column has been used to measure platelet adhesion, whether platelet interaction with glass beads represents physiologic processes remains unsettled. In an attempt to obtain more physiologic platelet responses, plastic beads coated with type I collagen have been recently developed to replace glass beads. In this study, we analyzed the factors responsible for platelet retention in the collagen-coated-bead column and investigated its possible clinical applications. We pumped citrated whole-blood samples into columns at a fixed speed with an injection pump and calculated platelet-retention rates by measuring platelet counts before and after passage through the columns. The platelet-retention rates, which were highly reproducible with samples from healthy donors, were reduced in a patient with glycoprotein (GP) VI deficiency but not in patients with type III von Willebrand disease. Anti-GPIIb/IIIa antibody and GRGDS peptide markedly inhibited platelet retention, whereas inhibition of the GPIb-von Willebrand factor or GPIa/IIa-collagen interaction had no effect. Data on the effects of various antiplatelet agents (including the antithrombin agent argatroban, prostacyclin, acetylsalicylic acid, and the ADP scavenger creatine phosphate/creatine phosphokinase) support the usefulness of this assay method in clinical application. Our findings suggest that GPVI and GPIIb/IIIa but not the GPIb-von Willebrand factor interaction are mainly involved in platelet retention in this column.
{"title":"Mechanisms of platelet retention in the collagen-coated-bead column.","authors":"M. Kaneko, O. Cuyun-Lira, T. Takafuta, K. Suzuki-Inoue, K. Satoh, K. Ohtsuki, M. Ohnishi, M. Arai, Y. Yatomi, Y. Ozaki","doi":"10.1111/J.1538-7836.2003.TB05661.X","DOIUrl":"https://doi.org/10.1111/J.1538-7836.2003.TB05661.X","url":null,"abstract":"Although the glass-bead column has been used to measure platelet adhesion, whether platelet interaction with glass beads represents physiologic processes remains unsettled. In an attempt to obtain more physiologic platelet responses, plastic beads coated with type I collagen have been recently developed to replace glass beads. In this study, we analyzed the factors responsible for platelet retention in the collagen-coated-bead column and investigated its possible clinical applications. We pumped citrated whole-blood samples into columns at a fixed speed with an injection pump and calculated platelet-retention rates by measuring platelet counts before and after passage through the columns. The platelet-retention rates, which were highly reproducible with samples from healthy donors, were reduced in a patient with glycoprotein (GP) VI deficiency but not in patients with type III von Willebrand disease. Anti-GPIIb/IIIa antibody and GRGDS peptide markedly inhibited platelet retention, whereas inhibition of the GPIb-von Willebrand factor or GPIa/IIa-collagen interaction had no effect. Data on the effects of various antiplatelet agents (including the antithrombin agent argatroban, prostacyclin, acetylsalicylic acid, and the ADP scavenger creatine phosphate/creatine phosphokinase) support the usefulness of this assay method in clinical application. Our findings suggest that GPVI and GPIIb/IIIa but not the GPIb-von Willebrand factor interaction are mainly involved in platelet retention in this column.","PeriodicalId":23085,"journal":{"name":"The Journal of laboratory and clinical medicine","volume":"6 1","pages":"258-67"},"PeriodicalIF":0.0,"publicationDate":"2003-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79557677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cystic fibrosis of the pancreas.","authors":"Dale E Hammerschmidt","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23085,"journal":{"name":"The Journal of laboratory and clinical medicine","volume":"141 4","pages":"283"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22347069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-04-01DOI: 10.1016/S0016-5085(03)80659-5
H. Hori, H. Nakata, G. Iguchi, H. Yamada, K. Chihara, Hisamitsu Baba
{"title":"Oncogenic ras induces gastrin/CCKB receptor gene expression in human colon cancer cell lines LoVo and Colo320HSR.","authors":"H. Hori, H. Nakata, G. Iguchi, H. Yamada, K. Chihara, Hisamitsu Baba","doi":"10.1016/S0016-5085(03)80659-5","DOIUrl":"https://doi.org/10.1016/S0016-5085(03)80659-5","url":null,"abstract":"","PeriodicalId":23085,"journal":{"name":"The Journal of laboratory and clinical medicine","volume":"60 1","pages":"335-41"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88135939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A pile of rocks.","authors":"Dale E Hammerschmidt","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23085,"journal":{"name":"The Journal of laboratory and clinical medicine","volume":"140 6","pages":"419"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22180691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abbreviations: AdoHcy S-adenosylhomocysteine; AdoMet S-adenosylmethionine; ATP adenosine triphosphate; bHcy protein-bound Hcy; BHMT betaine-homocysteine methyltransferase; CBS cystathionine -synthase; DNA deoxyribonucleic acid; fHcy free Hcy; GFR glomerular filtration rate; Hcy homocysteine; HcyH reduced thiol form of Hcy; Km Michaelis-Menten constant; MeTHF 5 -methyltetrahydrofolate; MTHFR methylenetetrahydrofolate reductase; RNA ribonucleic acid; tHcy total Hcy
缩写词:adhcy s -腺苷型同型半胱氨酸;AdoMet S-adenosylmethionine;三磷酸腺苷;蛋白结合的Hcy;甜菜碱-同型半胱氨酸甲基转移酶;CBS半胱硫氨酸合成酶;DNA脱氧核糖核酸;fHcy自由Hcy;GFR肾小球滤过率;Hcy同型半胱氨酸;HcyH还原硫醇形式的Hcy;Km Michaelis-Menten常数;5 -甲基四氢叶酸;甲基四氢叶酸还原酶;RNA核糖核酸;它们都是Hcy
{"title":"Why are homocysteine levels increased in kidney failure? A metabolic approach.","authors":"H. Blom, A. D. De Vriese","doi":"10.1067/MLC.2002.122862","DOIUrl":"https://doi.org/10.1067/MLC.2002.122862","url":null,"abstract":"Abbreviations: AdoHcy S-adenosylhomocysteine; AdoMet S-adenosylmethionine; ATP adenosine triphosphate; bHcy protein-bound Hcy; BHMT betaine-homocysteine methyltransferase; CBS cystathionine -synthase; DNA deoxyribonucleic acid; fHcy free Hcy; GFR glomerular filtration rate; Hcy homocysteine; HcyH reduced thiol form of Hcy; Km Michaelis-Menten constant; MeTHF 5 -methyltetrahydrofolate; MTHFR methylenetetrahydrofolate reductase; RNA ribonucleic acid; tHcy total Hcy","PeriodicalId":23085,"journal":{"name":"The Journal of laboratory and clinical medicine","volume":"27 1","pages":"262-8"},"PeriodicalIF":0.0,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80701646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Polyenylphosphatidylcholine (PPC), a mixture of polyunsaturated phosphatidylcholines, protects against alcoholic and nonalcoholic liver fibrosis in baboons and rats, respectively. In this study, we assessed the antifibrogenic action of dilinoleoylphosphatidylcholine (DLPC), the main phosphatidylcholine species of PPC, against transforming growth factor-beta1-mediated expression of alpha1(I) procollagen, tissue inhibitor of metallopreoteinase-1 (TIMP-1) and matrix metalloproteinase-13 (MMP-13) in cultured rat hepatic stellate cells (HSCs). In primary culture-activated HSCs, TGF-beta1 up-regulated the alpha1(I) procollagen mRNA level with a concomitant increase in type I collagen accumulation in culture media. Whereas TIMP-1 mRNA levels and TIMP-1 accumulation in media were also increased by TGF-beta1, MMP-13 mRNA expression and MMP-13 concentration in media were not altered. DLPC fully blocked TGF-beta1-induced increase in alpha1(I) procollagen mRNA expression and decreased collagen accumulation in media. Whereas TIMP-1 mRNA level and TIMP-1 accumulation in media were decreased by DLPC, MMP-13 mRNA expression and MMP-13 concentration in media were not changed by this treatment. Palmitoyl-linoleoylphosphatidylcholine (PLPC), the second most abundant component of PPC, had no effect on the concentrations of collagen, TIMP-1, and MMP-13 in HSC culture. We conclude that DLPC prevents TGF-beta1-mediated HSC fibrogenesis through down-regulation of alpha1(I) procollagen and TIMP-1 mRNA expression. The latter effect leads to a decreased accumulation of TIMP-1 that, in the presence of unchanged MMP-13 mRNA expression and MMP-13 concentration, results in a larger ratio of MMP-13/TIMP-1 concentrations in the culture media, favoring collagen degradation and lesser collagen accumulation. This effect of DLPC may explain, at least in part, the antifibrogenic action of PPC against alcoholic and other fibrotic disorders of the liver.
{"title":"Dilinoleoylphosphatidylcholine prevents transforming growth factor-beta1-mediated collagen accumulation in cultured rat hepatic stellate cells.","authors":"Q. Cao, K. Mak, C. Lieber","doi":"10.1067/MLC.2002.121853","DOIUrl":"https://doi.org/10.1067/MLC.2002.121853","url":null,"abstract":"Polyenylphosphatidylcholine (PPC), a mixture of polyunsaturated phosphatidylcholines, protects against alcoholic and nonalcoholic liver fibrosis in baboons and rats, respectively. In this study, we assessed the antifibrogenic action of dilinoleoylphosphatidylcholine (DLPC), the main phosphatidylcholine species of PPC, against transforming growth factor-beta1-mediated expression of alpha1(I) procollagen, tissue inhibitor of metallopreoteinase-1 (TIMP-1) and matrix metalloproteinase-13 (MMP-13) in cultured rat hepatic stellate cells (HSCs). In primary culture-activated HSCs, TGF-beta1 up-regulated the alpha1(I) procollagen mRNA level with a concomitant increase in type I collagen accumulation in culture media. Whereas TIMP-1 mRNA levels and TIMP-1 accumulation in media were also increased by TGF-beta1, MMP-13 mRNA expression and MMP-13 concentration in media were not altered. DLPC fully blocked TGF-beta1-induced increase in alpha1(I) procollagen mRNA expression and decreased collagen accumulation in media. Whereas TIMP-1 mRNA level and TIMP-1 accumulation in media were decreased by DLPC, MMP-13 mRNA expression and MMP-13 concentration in media were not changed by this treatment. Palmitoyl-linoleoylphosphatidylcholine (PLPC), the second most abundant component of PPC, had no effect on the concentrations of collagen, TIMP-1, and MMP-13 in HSC culture. We conclude that DLPC prevents TGF-beta1-mediated HSC fibrogenesis through down-regulation of alpha1(I) procollagen and TIMP-1 mRNA expression. The latter effect leads to a decreased accumulation of TIMP-1 that, in the presence of unchanged MMP-13 mRNA expression and MMP-13 concentration, results in a larger ratio of MMP-13/TIMP-1 concentrations in the culture media, favoring collagen degradation and lesser collagen accumulation. This effect of DLPC may explain, at least in part, the antifibrogenic action of PPC against alcoholic and other fibrotic disorders of the liver.","PeriodicalId":23085,"journal":{"name":"The Journal of laboratory and clinical medicine","volume":"73 1","pages":"202-10"},"PeriodicalIF":0.0,"publicationDate":"2002-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85340182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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