INFLUENCE OF ZINC ALIMENTARY TREATMENT ON NORMAL AND PATHOLOGICAL MOTOR BEHAVIOR OF RATS

A. Yakimovskii
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引用次数: 1

Abstract

Chronic experiments were performed on rats to study the influence of prolonged acetic zinc alimentary treatment on normal (spontaneous movement in “open field and condition active avoidance reflex in “shuttle box”) and abnormal (choreomyoclonic hyperkinesia, produced by intrastriatal microinjections GABA-A receptors antagonist picrotoxin  2 mcg) motor behavior. 4 mg acetic zinc is used by rats with food ball once a day. 12 mg zinc сonsumption by rats per week did not affected on normal behavior. While 24 mg is produced smaller negative effects on rats reflex performance to 6570% correct responses (of total present during the experiment) but to improved condition avoidance behavior, violated by picrotoxinin rats and reduce the reproducibility of picrotoxin-induced choreo-mioclonic hyperkinesis (human Huntington disease hyperkinesis analog). The influence of zinc on motor behavior depending on its dose and mode of administration is discussed.
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锌营养处理对大鼠正常和病理运动行为的影响
采用慢性实验研究醋酸锌长期消化处理对大鼠正常(“开场自发运动”和“穿梭箱”条件主动回避反射)和异常(胃内微注射GABA-A受体拮抗剂微毒素所致的choreomicononic hyperexercise)运动行为的影响。醋酸锌4 mg,大鼠每日1次。大鼠每周摄入12毫克锌对正常行为没有影响。虽然24mg对大鼠反射性能产生较小的负面影响,但对65% - 70%的正确反应(实验中存在的总数)产生负面影响,但对改善条件回避行为,由微旋毒素大鼠违反,并降低微旋毒素诱导的舞蹈症-微旋阵挛性过度运动(人类亨廷顿病过度运动类似物)的可重复性。讨论了锌对运动行为的影响取决于其剂量和给药方式。
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